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Tbio
ABCA7
ATP-binding cassette sub-family A member 7

Protein Summary
Description
Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This full transporter has been detected predominantly in myelo-lymphatic tissues with the highest expression in peripheral leukocytes, thymus, spleen, and bone marrow. The function of this protein is not yet known; however, the expression pattern suggests a role in lipid h ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263094
  • ENSP00000263094
  • ENSG00000064687
  • ENST00000433129
  • ENSP00000414062
  • ENST00000435683
  • ENSP00000465322

Symbol
  • AD9
  • ABCX
  • ABCA-SSN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
biological process
0.97
cellular component
0.88
protein domain
0.85
transcription factor binding site profile
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 161.68   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 154   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 161.68   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (85)
HTR3A
Tclin
Family:  IC
Novelty:  0.00217443
p_int:  0.999994347
p_ni:  0.000005586
p_wrong:  6.7e-8
Score:  0.194
Data Source:  BioPlex,STRINGDB
GABRA3
Tclin
Family:  IC
Novelty:  0.02180091
p_int:  0.998360459
p_ni:  0.001347275
p_wrong:  0.000292265
Score:  0.195
Data Source:  BioPlex,STRINGDB
APOA1
Tbio
Novelty:  0.0001216
Score:  0.925
Data Source:  Reactome,STRINGDB
ABCD4
Tbio
Family:  Transporter
Novelty:  0.04096359
Score:  0.863
Data Source:  STRINGDB
PICALM
Tbio
Novelty:  0.00800832
Score:  0.86
Data Source:  STRINGDB
BIN1
Tbio
Novelty:  0.00312612
Score:  0.839
Data Source:  STRINGDB
MS4A6A
Tbio
Novelty:  0.04742307
Score:  0.832
Data Source:  STRINGDB
CD2AP
Tbio
Novelty:  0.00603034
Score:  0.799
Data Source:  STRINGDB
CLU
Tbio
Novelty:  0.00054776
Score:  0.788
Data Source:  STRINGDB
ATP12A
Tchem
Family:  Transporter
Novelty:  0.00008793
Score:  0.783
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
ABC transporters in lipid homeostasis (R-HSA-1369062)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporters in lipid homeostasis
Reactome
ABC-family proteins mediated transport
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
ABC transporters in lipid homeostasis
ABC-family proteins mediated transport
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (37)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
Alzheimers_University_of_Toronto
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (53)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Alzheimer disease
8
5
0
1.8
96.1
3
2
0
1.2
95.5
red blood cell distribution width
4
3
5
93.2
reticulocyte count
7
3
8
92.7
neutrophil count
7
6
7
92.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Alzheimer disease
0
1.8
96.1
0
1.2
95.5
red blood cell distribution width
5
93.2
reticulocyte count
8
92.7
neutrophil count
7
92.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ATP binding cassette subfamily A member 7
704976
Mouse
MGI:1351646
27403
Rat
RGD:1303134
299609
Dog
ATP binding cassette subfamily A member 7
VGNC:37429
485090
Cow
ATP binding cassette subfamily A member 7
VGNC:25461
511762
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ATP binding cassette subfamily A member 7
Mouse
Rat
Dog
ATP binding cassette subfamily A member 7
Cow
ATP binding cassette subfamily A member 7
Publication Statistics
PubMed Score 161.68
PubMed score by year
PubTator Score 109.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title