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Tbio
ABCA5
ATP-binding cassette sub-family A member 5

Protein Summary
Description
May play a role in the processing of autolysosomes. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This gene is clustered among 4 other ABC1 family members on 17q24, but neither the substrate nor the function of this gene is known. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000392676
  • ENSP00000376443
  • ENSG00000154265
  • ENST00000588877
  • ENSP00000467882

Symbol
  • KIAA1888
  • HTC3
  • ABC13
  • EST90625
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
virus perturbation
0.97
histone modification site profile
0.85
protein domain
0.85
cell type or tissue
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.48   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.48   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (20)
ELP6
Tbio
Novelty:  0.01229878
Score:  0.8
Data Source:  STRINGDB
ABCD4
Tbio
Family:  Transporter
Novelty:  0.04096359
Score:  0.709
Data Source:  STRINGDB
CCDC137
Tdark
Novelty:  1.16145052
Score:  0.692
Data Source:  STRINGDB
ABCF3
Tdark
Family:  Transporter
Novelty:  0.21595418
Score:  0.658
Data Source:  STRINGDB
ABCF1
Tbio
Family:  Transporter
Novelty:  0.03900964
Score:  0.592
Data Source:  STRINGDB
CFAP46
Tdark
Novelty:  0.73818628
Score:  0.571
Data Source:  STRINGDB
TTYH2
Tbio
Family:  IC
Novelty:  0.19796461
Score:  0.54
Data Source:  STRINGDB
MAP2K6
Tchem
Family:  Kinase
Novelty:  0.00569655
Score:  0.487
Data Source:  STRINGDB
ERMARD
Tdark
Novelty:  0.3424066
Score:  0.471
Data Source:  STRINGDB
HMGCS1
Tchem
Family:  Enzyme
Novelty:  0.01089288
Score:  0.47
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
ABC transporters in lipid homeostasis (R-HSA-1369062)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporters in lipid homeostasis
Reactome
ABC-family proteins mediated transport
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
ABC transporters in lipid homeostasis
ABC-family proteins mediated transport
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
4
5
94.5
apolipoprotein B measurement
2
2
3
89.2
corneal hysteresis
1
1
1
81.3
total cholesterol measurement
1
1
1
78.6
serum albumin measurement
1
1
1
48.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
5
94.5
apolipoprotein B measurement
3
89.2
corneal hysteresis
1
81.3
total cholesterol measurement
1
78.6
serum albumin measurement
1
48.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily A member 5
VGNC:6318
454848
Mouse
MGI:2386607
217265
Rat
RGD:628661
286970
Dog
ATP binding cassette subfamily A member 5
VGNC:37428
480455
Horse
ATP binding cassette subfamily A member 5
VGNC:14904
100053093
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily A member 5
Mouse
Rat
Dog
ATP binding cassette subfamily A member 5
Horse
ATP binding cassette subfamily A member 5
Publication Statistics
PubMed Score 21.48
PubMed score by year
PubTator Score 10.61
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title