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Tbio
ABCA2
ATP-binding cassette sub-family A member 2

Protein Summary
Description
Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is highly expressed in brain tissue and may play a role in macrophage lipid metabolism and neural development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341511
  • ENSP00000344155
  • ENSG00000107331
  • ENST00000371605
  • ENSP00000360666

Symbol
  • ABC2
  • KIAA1062
  • ABC2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
cellular component
0.86
protein domain
0.85
kinase perturbation
0.84
transcription factor
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.66   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 202   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.66   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (57)
ZNRF4
Tbio
Novelty:  0.16505328
p_int:  0.999975542
p_ni:  0.000024454
p_wrong:  4e-9
Score:  0.159
Data Source:  BioPlex,STRINGDB
LMAN2L
Tbio
Novelty:  0.04364985
p_int:  0.999925427
p_ni:  0.000074559
p_wrong:  1.4e-8
Score:  0.177
Data Source:  BioPlex,STRINGDB
PON2
Tbio
Family:  Enzyme
Novelty:  0.00414855
p_int:  0.999782765
p_ni:  0.000217198
p_wrong:  3.7e-8
Score:  0.224
Data Source:  BioPlex,STRINGDB
BTNL3
Tdark
Novelty:  0.27343899
p_int:  0.999412348
p_ni:  0.000585263
p_wrong:  0.000002389
Data Source:  BioPlex
HTR3A
Tclin
Family:  IC
Novelty:  0.00217443
p_int:  0.997211201
p_ni:  0.002495947
p_wrong:  0.000292852
Data Source:  BioPlex
HFE
Tbio
Novelty:  0.00042077
p_int:  0.996452293
p_ni:  0.003231799
p_wrong:  0.000315908
Score:  0.31
Data Source:  BioPlex,STRINGDB
PTCH1
Tbio
Novelty:  0.00077635
p_int:  0.98590629
p_ni:  0.013651616
p_wrong:  0.000442094
Data Source:  BioPlex
ABCD4
Tbio
Family:  Transporter
Novelty:  0.04096359
Score:  0.952
Data Source:  STRINGDB
ABCB6
Tbio
Family:  Transporter
Novelty:  0.00552057
Score:  0.926
Data Source:  STRINGDB
ABCG5
Tbio
Family:  Transporter
Novelty:  0.00340812
Score:  0.924
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
ABC transporters in lipid homeostasis (R-HSA-1369062)

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporters in lipid homeostasis
Reactome
ABC-family proteins mediated transport
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
ABC transporters in lipid homeostasis
ABC-family proteins mediated transport
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
3
4
91.5
monocyte percentage of leukocytes
2
2
2
88
leukocyte count
2
2
3
70.2
central corneal thickness
3
2
0
2.9
69.8
lymphocyte percentage of leukocytes
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
4
91.5
monocyte percentage of leukocytes
2
88
leukocyte count
3
70.2
central corneal thickness
0
2.9
69.8
lymphocyte percentage of leukocytes
1
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ATP binding cassette subfamily A member 2
721631
Mouse
MGI:99606
11305
Rat
RGD:620238
79248
Dog
ATP binding cassette subfamily A member 2
VGNC:37425
480669
Horse
ATP binding cassette subfamily A member 2
VGNC:14901
100067889
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ATP binding cassette subfamily A member 2
Mouse
Rat
Dog
ATP binding cassette subfamily A member 2
Horse
ATP binding cassette subfamily A member 2
Publication Statistics
PubMed Score 52.66
PubMed score by year
PubTator Score 125.99
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title