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Tbio
AATK
Serine/threonine-protein kinase LMTK1

Protein Summary
Description
May be involved in neuronal differentiation. The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326724
  • ENSP00000324196
  • ENSG00000181409
  • ENST00000374792
  • ENSP00000363924

Symbol
  • AATYK
  • KIAA0641
  • LMR1
  • LMTK1
  • LMR1
  • AATYK
  • LMTK1
  • p35BP
  • AATYK1
  • PPP1R77
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
gene perturbation
0.86
disease perturbation
0.83
protein domain
0.73
cell line
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.4   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 191   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.4   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0