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Tbio
AASS
Alpha-aminoadipic semialdehyde synthase, mitochondrial

Protein Summary
Description
Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively. This gene encodes a bifunctional enzyme that catalyzes the first two steps in the mammalian lysine degradation pathway. The N-terminal and the C-terminal portions of this enzyme contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively, resulting in the conversion of lysine to alpha-aminoadipic semialdehyde. Mutations in this gene are associated with familial hyperlysinemia. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393376
  • ENSP00000377040
  • ENSG00000008311
  • ENST00000417368
  • ENSP00000403768

Symbol
  • LKRSDH
  • LORSDH
  • LKR/SDH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
disease perturbation
0.83
PubMedID
0.83
kinase perturbation
0.71
histone modification site profile
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.52   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 189   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.52   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (70)
ARHGEF39
Tdark
Novelty:  0.30447134
p_int:  0.955769318
p_ni:  0.044230682
Data Source:  BioPlex
VPS37D
Tdark
Novelty:  1.44882563
p_int:  0.920588539
p_ni:  0.079411461
Score:  0.54
Data Source:  BioPlex,STRINGDB
MGARP
Tbio
Novelty:  0.02883753
p_int:  0.872796497
p_ni:  0.127203503
Data Source:  BioPlex
LAGE3
Tdark
Novelty:  0.02099961
p_int:  0.783692847
p_ni:  0.216307153
Data Source:  BioPlex
AASDH
Tbio
Family:  Enzyme
Novelty:  0.17181708
Score:  0.978
Data Source:  STRINGDB
ALDH7A1
Tbio
Family:  Enzyme
Novelty:  0.00069494
Score:  0.967
Data Source:  STRINGDB
PHYKPL
Tdark
Family:  Enzyme
Novelty:  0.23107386
Score:  0.953
Data Source:  STRINGDB
AASDHPPT
Tbio
Family:  Enzyme
Novelty:  0.00443438
Score:  0.929
Data Source:  STRINGDB
BTD
Tbio
Family:  Enzyme
Novelty:  0.01638573
Score:  0.82
Data Source:  STRINGDB
SCCPDH
Tbio
Family:  Enzyme
Novelty:  0.06603568
Score:  0.792
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (28)
Lysine catabolism (R-HSA-71064)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Lysine catabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Lysine catabolism
Metabolism
Metabolism of amino acids and derivatives
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
3.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
3.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aminoadipate-semialdehyde synthase
VGNC:4239
472493
Mouse
MGI:1353573
30956
Rat
RGD:1310811
296925
Dog
aminoadipate-semialdehyde synthase
VGNC:37419
482429
Horse
aminoadipate-semialdehyde synthase
VGNC:14895
100056260
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aminoadipate-semialdehyde synthase
Mouse
Rat
Dog
aminoadipate-semialdehyde synthase
Horse
aminoadipate-semialdehyde synthase
Publication Statistics
PubMed Score 33.52
PubMed score by year
PubTator Score 12.70
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title