You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
AARSD1
Alanyl-tRNA editing protein Aarsd1

Protein Summary
Description
Functions in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala). This locus represents naturally occurring readthrough transcription between the neighboring PTGES3L (prostaglandin E synthase 3 (cytosolic)-like) and AARSD1(alanyl-tRNA synthetase domain containing 1) genes on chromosome 17. The readthrough transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, May 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360221
  • ENSP00000353355
  • ENSG00000108825
  • ENST00000409399
  • ENSP00000386621
  • ENST00000421990
  • ENSP00000409924
  • ENST00000427569
  • ENSP00000400870
  • ENSG00000266967
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
kinase perturbation
0.66
cell line
0.65
transcription factor binding site profile
0.59
cell type or tissue
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.92   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 78   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.92   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
RGS20
Tbio
Novelty:  0.04087618
p_int:  0.999999954
p_ni:  4.6e-8
Data Source:  BioPlex
TRIM45
Tbio
Novelty:  0.03874681
p_int:  0.99999982
p_ni:  8e-9
p_wrong:  1.73e-7
Score:  0.807
Data Source:  BioPlex,STRINGDB
YKT6
Tbio
Novelty:  0.01591063
p_int:  0.999994704
p_ni:  0.000005296
Data Source:  BioPlex
MAP3K7
Tchem
Family:  Kinase
Novelty:  0.00540177
p_int:  0.999943975
p_ni:  0.000056025
Data Source:  BioPlex
DDHD2
Tbio
Family:  Enzyme
Novelty:  0.04306798
p_int:  0.999933411
p_ni:  0.000066552
p_wrong:  3.7e-8
Data Source:  BioPlex
NPHP3
Tbio
Novelty:  0.02857926
p_int:  0.999920057
p_ni:  0.000079943
Data Source:  BioPlex
C12orf74
Tdark
Novelty:  2.54545455
p_int:  0.999788072
p_ni:  0.000211928
Data Source:  BioPlex
ALKBH2
Tbio
Family:  Enzyme
Novelty:  0.02318716
p_int:  0.999670855
p_ni:  0.000085112
p_wrong:  0.000244033
Score:  0.181
Data Source:  BioPlex,STRINGDB
TAB1
Tchem
Family:  Kinase
Novelty:  0.00721424
p_int:  0.999627301
p_ni:  0.000372699
Data Source:  BioPlex
MED22
Tbio
Family:  Enzyme
Novelty:  0.07630387
p_int:  0.999574146
p_ni:  0.000425854
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (19)
Items per page:
1 – 5 of 19
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
87.8
neutrophil count
2
2
2
87.8
myeloid white cell count
1
1
1
71.9
myeloid white cell count
1
1
1
71.9
aspartate aminotransferase measurement
1
1
0
7.1
55.2
Items per page:
1 – 5 of 19
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
87.8
neutrophil count
2
87.8
myeloid white cell count
1
71.9
myeloid white cell count
1
71.9
aspartate aminotransferase measurement
0
7.1
55.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 0.92
PubMed score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title