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Tchem
AAK1
AP2-associated protein kinase 1

Protein Summary
Description
Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity. Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts wit ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000406297
  • ENSP00000385181
  • ENSG00000115977
  • ENST00000409085
  • ENSP00000386456

Symbol
  • KIAA1048
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
disease perturbation
0.99
transcription factor perturbation
0.98
kinase perturbation
0.97
molecular function
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.22   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 326   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.22   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 326   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 45
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (150)
AP2M1
Tbio
Novelty:  0.00769368
p_int:  0.999999998
p_ni:  2e-9
Score:  0.993
Data Source:  BioPlex,STRINGDB
AP2S1
Tbio
Novelty:  0.01931502
p_int:  0.999999996
p_ni:  3e-9
Score:  0.986
Data Source:  BioPlex,STRINGDB
REPS1
Tbio
Novelty:  0.08952347
p_int:  0.999999846
p_ni:  1.54e-7
p_wrong:  1e-9
Score:  0.996
Data Source:  BioPlex,STRINGDB
RUNDC3A
Tdark
Novelty:  0.23296904
p_int:  0.999995587
p_ni:  0.000004412
p_wrong:  1e-9
Score:  0.88
Data Source:  BioPlex,STRINGDB
DIEXF
Tbio
Novelty:  0.05892659
p_int:  0.999852794
p_ni:  0.000143843
p_wrong:  0.000003363
Data Source:  BioPlex
RALBP1
Tbio
Novelty:  0.01525176
p_int:  0.999714425
p_ni:  0.000285575
Score:  0.95
Data Source:  BioPlex,STRINGDB
AP2B1
Tbio
Novelty:  0.00921093
Score:  0.972
Data Source:  STRINGDB
EPS15
Tchem
Novelty:  0.00451447
Score:  0.971
Data Source:  STRINGDB
AP2A1
Tbio
Novelty:  0.08554974
Score:  0.965
Data Source:  STRINGDB
CLTB
Tbio
Novelty:  0.00931222
Score:  0.964
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Membrane Trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
4
2
4
89
hemoglobin measurement
2
1
2
57.3
body mass index
2
2
2
56.4
hematocrit
2
1
2
50.6
1
1
0
1.1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
4
89
hemoglobin measurement
2
57.3
body mass index
2
56.4
hematocrit
2
50.6
0
1.1
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
AP2 associated kinase 1
VGNC:1
736127
Macaque
AP2 associated kinase 1 [Source:HGNC Symbol;Acc:HGNC:19679]
Mouse
MGI:1098687
269774
Rat
RGD:1305520
500244
Dog
AP2 associated kinase 1
VGNC:37410
474625
Species
Name
OMA
EggNOG
Inparanoid
Chimp
AP2 associated kinase 1
Macaque
AP2 associated kinase 1 [Source:HGNC Symbol;Acc:HGNC:19679]
Mouse
Rat
Dog
AP2 associated kinase 1
Publication Statistics
PubMed Score 51.22
PubMed score by year
PubTator Score 15.17
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title