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Tbio
AAGAB
Alpha- and gamma-adaptin-binding protein p34

Protein Summary
Description
May be involved in endocytic recycling of growth factor receptors such as EGFR. The protein encoded by this gene interacts with the gamma-adaptin and alpha-adaptin subunits of complexes involved in clathrin-coated vesicle trafficking. Mutations in this gene are associated with type I punctate palmoplantar keratoderma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261880
  • ENSP00000261880
  • ENSG00000103591
  • ENST00000542650
  • ENSP00000440735
  • ENST00000561452
  • ENSP00000453263

Symbol
  • p34
  • KPPP1
  • PPKP1
  • PPKP1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
histone modification site profile
0.87
disease perturbation
0.74
transcription factor perturbation
0.74
cell type or tissue
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.04   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.04   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
AP2S1
Tbio
Novelty:  0.01931502
p_int:  0.999999993
p_ni:  7e-9
Score:  0.572
Data Source:  BioPlex,STRINGDB
AP1S2
Tbio
Novelty:  0.01413503
p_int:  0.999999234
p_ni:  7.66e-7
Score:  0.68
Data Source:  BioPlex,STRINGDB
ASAH1
Tchem
Family:  Enzyme
Novelty:  0.00374228
p_int:  0.999959399
p_ni:  0.000040601
Data Source:  BioPlex
EDRF1
Tbio
Novelty:  0.24333657
p_int:  0.99992748
p_ni:  0.000072519
p_wrong:  1e-9
Data Source:  BioPlex
AP1S3
Tbio
Novelty:  0.14425094
p_int:  0.999788517
p_ni:  0.000211296
p_wrong:  1.88e-7
Score:  0.603
Data Source:  BioPlex,STRINGDB
AP2A2
Tbio
Novelty:  0.08851191
p_int:  0.999702592
p_ni:  0.000297408
Score:  0.719
Data Source:  BioPlex,STRINGDB
AP2A1
Tbio
Novelty:  0.08554974
p_int:  0.999179348
p_ni:  0.000820652
Score:  0.407
Data Source:  BioPlex,STRINGDB
AP1G1
Tbio
Novelty:  0.03754132
p_int:  0.999146486
p_ni:  0.000853514
Score:  0.612
Data Source:  BioPlex,STRINGDB
STX4
Tbio
Novelty:  0.00831588
p_int:  0.996953129
p_ni:  0.003046871
Score:  0.186
Data Source:  BioPlex,STRINGDB
APBA2
Tbio
Novelty:  0.01654185
p_int:  0.993193261
p_ni:  0.006806731
p_wrong:  8e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
LIFEdb
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Disease Associations ()
No disease associations found
GWAS Traits (49)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
14
9
1
1.1
98.5
childhood onset asthma
2
3
0
1.2
96.7
heel bone mineral density
3
3
5
95
eosinophil count
3
4
5
94.8
eosinophil percentage of leukocytes
2
4
4
94.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
98.5
childhood onset asthma
0
1.2
96.7
heel bone mineral density
5
95
eosinophil count
5
94.8
eosinophil percentage of leukocytes
4
94.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
alpha and gamma adaptin binding protein
VGNC:53478
453720
Mouse
MGI:1914189
66939
Rat
RGD:621601
171435
Dog
alpha and gamma adaptin binding protein
VGNC:37409
610909
Horse
alpha and gamma adaptin binding protein
VGNC:14887
100052900
Species
Name
OMA
EggNOG
Inparanoid
Chimp
alpha and gamma adaptin binding protein
Mouse
Rat
Dog
alpha and gamma adaptin binding protein
Horse
alpha and gamma adaptin binding protein
Publication Statistics
PubMed Score 27.04
PubMed score by year
PubTator Score 144.35
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title