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Tchem
AADAC
Arylacetamide deacetylase

Protein Summary
Description
Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity. Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000232892
  • ENSP00000232892
  • ENSG00000114771

Symbol
  • DAC
  • DAC
  • CES5A1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.84
PubMedID
0.78
protein domain
0.58
cellular component
0.55
microRNA
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.67   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 171   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.67   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 171   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (35)
ATP8B3
Tdark
Family:  Transporter
Novelty:  0.44432131
Score:  0.707
Data Source:  STRINGDB
CES1
Tchem
Family:  Enzyme
Novelty:  0.00092608
Score:  0.701
Data Source:  STRINGDB
PIK3R6
Tbio
Family:  Enzyme
Novelty:  0.28270718
Score:  0.693
Data Source:  STRINGDB
DHDH
Tbio
Family:  Enzyme
Novelty:  0.00284827
Score:  0.689
Data Source:  STRINGDB
CES3
Tbio
Family:  Enzyme
Novelty:  0.00938734
Score:  0.68
Data Source:  STRINGDB
SUCNR1
Tchem
Family:  GPCR
Novelty:  0.01482891
Score:  0.678
Data Source:  STRINGDB
CES2
Tchem
Family:  Enzyme
Novelty:  0.00177726
Score:  0.674
Data Source:  STRINGDB
P2RY1
Tchem
Family:  GPCR
Novelty:  0.00203299
Score:  0.637
Data Source:  STRINGDB
SFT2D3
Tdark
Novelty:  31.35862045
Score:  0.626
Data Source:  STRINGDB
ARHGEF26
Tbio
Novelty:  0.09349583
Score:  0.62
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Biological oxidations (R-HSA-211859)

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Find Similar Targets
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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Metabolism
Reactome
Phase I - Functionalization of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Metabolism
Phase I - Functionalization of compounds
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
64.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
64.4
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
arylacetamide deacetylase
VGNC:11317
460785
Macaque
arylacetamide deacetylase
709031
Mouse
MGI:1915008
67758
Rat
RGD:631440
57300
Dog
arylacetamide deacetylase
VGNC:37404
477115
Species
Name
OMA
EggNOG
Inparanoid
Chimp
arylacetamide deacetylase
Macaque
arylacetamide deacetylase
Mouse
Rat
Dog
arylacetamide deacetylase
Publication Statistics
PubMed Score 53.67
PubMed score by year
PubTator Score 139.42
PubTator score by year
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Related Publications
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PMID
Year
Title