Tbio AHRR Aryl hydrocarbon receptor repressor

Protein Summary

Description

Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site. The protein encoded by this gene participates in the aryl hydrocarbon receptor (AhR) signaling cascade, which mediates dioxin toxicity, and is involved in regulation of cell growth and differentiation. It functions as a feedback modulator by repressing AhR-dependent gene expression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2011]

Uniprot Accession IDs

• A9YTQ3
• A7MBN5
• D6RAZ1
• Q9HAZ3
• Q9ULI6
• AhR repressor

Gene Name

• AHRR

Ensembl ID

• ENST00000316418
• ENSP00000323816
• ENSG00000063438
• ENST00000505113
• ENSP00000424601

Symbol

• BHLHE77
• KIAA1234
• AHH
• AHHR
• bHLHe77

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.69
gene perturbation	0.65
cellular component	0.63
disease	0.6
biological term	0.55

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Basic Helix-loop-helix Transcription Factor / Aryl Hydrocarbon Receptor Repressor

Protein / Receptor / Aryl Hydrocarbon Receptor Repressor

DTO Classes

Protein / Transcription Factor / Basic Helix-loop-helix Transcription Factor / Aryl Hydrocarbon Receptor Repressor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.7   (req: < 5)

Gene RIFs: 78   (req: <= 3)

Antibodies: 113   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.7   (req: >= 5)

Gene RIFs: 78   (req: > 3)

Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0