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Tbio
AHRR
Aryl hydrocarbon receptor repressor

Protein Summary
Description
Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site. The protein encoded by this gene participates in the aryl hydrocarbon receptor (AhR) signaling cascade, which mediates dioxin toxicity, and is involved in regulation of cell growth and differentiation. It functions as a feedback modulator by repressing AhR-dependent gene expression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316418
  • ENSP00000323816
  • ENSG00000063438
  • ENST00000505113
  • ENSP00000424601

Symbol
  • BHLHE77
  • KIAA1234
  • AHH
  • AHHR
  • bHLHe77
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.69
gene perturbation
0.65
cellular component
0.63
disease
0.6
biological term
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.49   (req: < 5)
Gene RIFs: 48   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.49   (req: >= 5)
Gene RIFs: 48   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
CYP1A1
Tchem
Novelty:  0.0002404
Score:  0.978
Data Source:  STRINGDB
ARNT
Tbio
Family:  TF
Novelty:  0.00183071
Score:  0.966
Data Source:  Reactome,STRINGDB
ARNT2
Tbio
Family:  TF
Novelty:  0.01485424
Score:  0.94
Data Source:  Reactome,STRINGDB
MYO1G
Tbio
Novelty:  0.01119203
Score:  0.775
Data Source:  STRINGDB
F2RL3
Tchem
Family:  GPCR
Novelty:  0.01953308
Score:  0.73
Data Source:  STRINGDB
FLYWCH1
Tdark
Novelty:  0.45235856
Score:  0.719
Data Source:  STRINGDB
ANKRD9
Tdark
Novelty:  0.43181793
Score:  0.714
Data Source:  STRINGDB
AIP
Tbio
Novelty:  0.00869592
Score:  0.676
Data Source:  STRINGDB
ANKRA2
Tbio
Novelty:  0.19358401
Score:  0.673
Data Source:  STRINGDB
CYP1B1
Tchem
Novelty:  0.00090917
Score:  0.645
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Aryl hydrocarbon receptor signalling (R-HSA-8937144)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aryl hydrocarbon receptor signalling
Reactome
Biological oxidations
Reactome
Cytochrome P450 - arranged by substrate type
Reactome
Endogenous sterols
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Aryl hydrocarbon receptor signalling
Biological oxidations
Cytochrome P450 - arranged by substrate type
Endogenous sterols
Metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
3
2
3
85.6
hematocrit
2
1
2
76.1
red blood cell density measurement
1
1
1
68.3
BMI-adjusted hip circumference
2
4
4
57.1
glomerular filtration rate
2
2
1
6.3
53.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
3
85.6
hematocrit
2
76.1
red blood cell density measurement
1
68.3
BMI-adjusted hip circumference
4
57.1
glomerular filtration rate
1
6.3
53.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
programmed cell death 6
723043
Mouse
MGI:1333776
11624
Rat
RGD:1559857
498999
Dog
aryl-hydrocarbon receptor repressor
VGNC:37729
488074
Horse
aryl-hydrocarbon receptor repressor
VGNC:15180
100057633
Species
Name
OMA
EggNOG
Inparanoid
Macaque
programmed cell death 6
Mouse
Rat
Dog
aryl-hydrocarbon receptor repressor
Horse
aryl-hydrocarbon receptor repressor
Publication Statistics
PubMed Score 96.49
PubMed score by year
PubTator Score 111.70
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title