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Tbio
KPNA7
Importin subunit alpha-8

Protein Summary
Description
Functions in nuclear protein import. The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import, but exhibits different nuclear localization signal binding specificity compared to other members of the family. A pseudogene of this gene has been defined on chromosome 5. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327442
  • ENSP00000330878
  • ENSG00000185467
  • ENST00000640158
  • ENSP00000491331
  • ENSG00000284068

Symbol
  • IPOA8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
PubMedID
0.54
cell line
0.5
cellular component
0.47
tissue
0.36


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.25   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 42   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.25   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (112)
KPNB1
Tbio
Novelty:  0.01469696
Score:  0.954
Data Source:  STRINGDB
IL1F10
Tbio
Novelty:  0.01868526
Score:  0.853
Data Source:  STRINGDB
RCC1
Tbio
Novelty:  0.00260884
Score:  0.827
Data Source:  STRINGDB
PLK1
Tchem
Family:  Kinase
Novelty:  0.00062799
Score:  0.824
Data Source:  STRINGDB
RANBP3
Tbio
Novelty:  0.02563424
Score:  0.816
Data Source:  STRINGDB
BTN3A1
Tchem
Novelty:  0.02572232
Score:  0.807
Data Source:  STRINGDB
CCNB2
Tbio
Novelty:  0.00672914
Score:  0.799
Data Source:  STRINGDB
CDK1
Tchem
Family:  Kinase
Novelty:  0.00040776
Score:  0.786
Data Source:  STRINGDB
CSE1L
Tbio
Novelty:  0.00748892
Score:  0.774
Data Source:  STRINGDB
CCNB3
Tbio
Novelty:  0.01885821
Score:  0.748
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Host Interactions with Influenza Factors
Reactome
ISG15 antiviral mechanism
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
Cytokine Signaling in Immune system
Disease
Host Interactions with Influenza Factors
ISG15 antiviral mechanism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (26)
Items per page:
1 – 5 of 26
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
2
2
78.7
testosterone measurement
1
2
2
78.7
lymphocyte count
1
1
1
75.5
lymphocyte count
1
1
1
75.5
mean corpuscular volume
1
1
1
57.8
Items per page:
1 – 5 of 26
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
78.7
testosterone measurement
2
78.7
lymphocyte count
1
75.5
lymphocyte count
1
75.5
mean corpuscular volume
1
57.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
karyopherin subunit alpha 7
VGNC:7398
463566
Macaque
karyopherin subunit alpha 7
707357
Mouse
MGI:2141165
381686
Rat
RGD:1594749
690504
Dog
karyopherin subunit alpha 7
VGNC:42505
489863
Species
Name
OMA
EggNOG
Inparanoid
Chimp
karyopherin subunit alpha 7
Macaque
karyopherin subunit alpha 7
Mouse
Rat
Dog
karyopherin subunit alpha 7
Publication Statistics
PubMed Score 12.25
PubMed score by year
PubTator Score 5.24
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title