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Tbio
COL6A5
Collagen alpha-5(VI) chain

Protein Summary
Description
Collagen VI acts as a cell-binding protein. This gene encodes a member of the collagen superfamily of proteins. The encoded protein contains multiple von Willebrand factor A-like domains and may interact with the alpha 1 and alpha 2 chains of collagen VI to form the complete collagen VI trimer. Polymorphisms in this gene may be linked to dermal phenotypes, such as eczema. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.66
cell type or tissue
0.63
cell line
0.55
transcription factor
0.54
gene perturbation
0.5


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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.54   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.54   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
0
5.9
38
1
1
0
4.8
27.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
0
5.9
38
0
4.8
27.9
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:3648134
665033
Rat
RGD:1565804
501047
Dog
collagen type VI alpha 5 chain
VGNC:39482
485659
Pig
collagen type VI alpha 5 chain
100515967
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
collagen type VI alpha 5 chain
Pig
collagen type VI alpha 5 chain
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-A8TX70-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (21)
Assembly of collagen fibrils and other multimeric structures (R-HSA-2022090)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Axon guidance
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen chain trimerization
Reactome
Collagen formation
Name
Explore in Pharos
Explore in Source
Assembly of collagen fibrils and other multimeric structures
Axon guidance
Collagen biosynthesis and modifying enzymes
Collagen chain trimerization
Collagen formation
Protein-Protein Interactions (94)
1 – 10 of 94
COL6A1
Tbio
Novelty: 0.00644855
Score: 0.919
Data Source: STRINGDB
COL6A2
Tbio
Novelty: 0.01275082
Score: 0.918
Data Source: STRINGDB
COL6A3
Tbio
Novelty: 0.00805254
Score: 0.918
Data Source: STRINGDB
COL12A1
Tbio
Novelty: 0.0239421
Score: 0.916
Data Source: STRINGDB
COL4A4
Tbio
Novelty: 0.00833684
Score: 0.914
Data Source: STRINGDB
COL11A1
Tbio
Novelty: 0.00594683
Score: 0.911
Data Source: STRINGDB
COL4A5
Tbio
Novelty: 0.00283701
Score: 0.911
Data Source: STRINGDB
COL28A1
Tdark
Novelty: 0.95671561
Score: 0.911
Data Source: STRINGDB
COL4A6
Tbio
Novelty: 0.02524039
Score: 0.909
Data Source: STRINGDB
COL1A1
Tbio
Novelty: 0.00063584
Score: 0.908
Data Source: STRINGDB
Publication Statistics
PubMed Score  13.54

PubMed score by year
PubTator Score  9.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer