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Tbio
FOXO6
Forkhead box protein O6

Protein Summary
Description
Transcriptional activator.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000641094
  • ENSP00000493184
  • ENSG00000204060
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.57
cell line
0.54
cell type or tissue
0.53
tissue
0.53
chemical
0.43


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.3   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 49   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.3   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
2
3
96.2
intelligence
4
8
5
6
92.3
vitamin D measurement
2
2
2
87.4
self reported educational attainment
2
2
2
74.8
1
1
1
19.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
96.2
intelligence
5
6
92.3
vitamin D measurement
2
87.4
self reported educational attainment
2
74.8
1
19.4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-A8MYZ6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (22)
AKT phosphorylates targets in the nucleus (R-HSA-198693)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AKT phosphorylates targets in the nucleus
Reactome
Constitutive Signaling by AKT1 E17K in Cancer
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
FOXO-mediated transcription
Name
Explore in Pharos
Explore in Source
AKT phosphorylates targets in the nucleus
Constitutive Signaling by AKT1 E17K in Cancer
Disease
Diseases of signal transduction
FOXO-mediated transcription
Gene Ontology Terms (13)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Protein-Protein Interactions (56)
1 – 10 of 56
AKT1
Tchem
Family: Kinase
Novelty: 0.00003185
Score: 0.977
Data Source: STRINGDB
CDK2
Tchem
Family: Kinase
Novelty: 0.00032118
Score: 0.877
Data Source: STRINGDB
STK4
Tchem
Family: Kinase
Novelty: 0.02104423
Score: 0.848
Data Source: STRINGDB
PRMT1
Tchem
Family: Epigenetic
Novelty: 0.0032916
Score: 0.845
Data Source: STRINGDB
STK11
Tchem
Family: Kinase
Novelty: 0.00073247
Score: 0.844
Data Source: STRINGDB
MAPK1
Tchem
Family: Kinase
Novelty: 0.00061058
Score: 0.826
Data Source: STRINGDB
IKBKB
Tchem
Family: Kinase
Novelty: 0.00090202
Score: 0.824
Data Source: STRINGDB
SETD7
Tchem
Family: Epigenetic
Novelty: 0.00610155
Score: 0.824
Data Source: STRINGDB
MAPK3
Tchem
Family: Kinase
Novelty: 0.00012969
Score: 0.821
Data Source: STRINGDB
CHUK
Tchem
Family: Kinase
Novelty: 0.00151532
Score: 0.817
Data Source: STRINGDB
Publication Statistics
PubMed Score  36.30

PubMed score by year
PubTator Score  14.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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