Tbio KCNU1 Potassium channel subfamily U member 1

Protein Summary

Description

Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May represent the primary spermatozoan K(+) current. In contrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+). Critical for fertility. May play an important role in sperm osmoregulation required for the acquisition of normal morphology and motility when faced with osmotic challenges, such as those experienced after mixing with seminal fluid and entry into the vagina. This gene encodes a member of the potassium channel family of proteins. The encoded voltage-gated ion channel allows the outward flow of potassium ions during plasma membrane hyperpolarization in sperm. Opening of this channel may be regulated by calcium ion levels. Homozygous knockout mice that lack the related mouse gene exhibit male sterility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Uniprot Accession IDs

• A8MYU2

Gene Name

• KCNU1

Ensembl ID

• ENST00000399881
• ENSP00000382770
• ENSG00000215262

Symbol

• KCNMA3
• KCNMC1
• SLO3
• KCa5
• Slo3
• KCNMC1
• KCa5.1
• Kcnma3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.9
molecular function	0.86
cell type or tissue	0.67
cell line	0.61
tissue	0.54

Protein Classes

DTO Classes

Protein / Ion Channel / Potassium Channel Family / Calcium-activated Subfamily / Kca5.1/kcnu1 Sub-subfamily / Potassium Channel Subfamily U Member 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.11   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 68   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.11   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0