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Tdark
KRTAP9-1
Keratin-associated protein 9-1

Protein Summary
Description
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398470
  • ENSP00000381488
  • ENSG00000240542

Symbol
  • KAP9.1
  • KRTAP9.1
  • KRTAP9L3
  • KAP9.1
  • KRTAP9L3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.52
cellular component
0.36
small molecule perturbation
0.17
protein domain
0.15
PubMedID
0.14


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.14   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.14   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (2)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Gene Ontology Terms (3)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (67)
1 – 10 of 67
KRTAP12-1
Tdark
Novelty: 0.63157895
Score: 0.61
Data Source: STRINGDB
KRTAP11-1
Tdark
Novelty: 0.23575639
Score: 0.576
Data Source: STRINGDB
KRTAP27-1
Tdark
Novelty: 4
Score: 0.571
Data Source: STRINGDB
KRTAP19-4
Tdark
Score: 0.547
Data Source: STRINGDB
KRTAP1-4
Tdark
Novelty: 0.5
Score: 0.544
Data Source: STRINGDB
KRTAP13-3
Tdark
Novelty: 2.5
Score: 0.538
Data Source: STRINGDB
FBXO16
Tdark
Novelty: 0.68965517
Score: 0.537
Data Source: STRINGDB
KRTAP23-1
Tdark
Score: 0.518
Data Source: STRINGDB
KRTAP6-2
Tdark
Novelty: 1.42857143
Score: 0.515
Data Source: STRINGDB
KRT85
Tbio
Novelty: 0.09356257
Score: 0.512
Data Source: STRINGDB
Publication Statistics
PubMed Score  0.14

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer