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Tdark
NUDT19
Nucleoside diphosphate-linked moiety X motif 19

Protein Summary
Description
Coenzyme A diphosphatase that mediates the hydrolysis of a wide range of CoA esters, including choloyl-CoA and branched-chain fatty-acyl-CoA esters. At low substrate concentrations medium and long-chain fatty-acyl-CoA esters are the primary substrates (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397061
  • ENSP00000380251
  • ENSG00000213965

Symbol
  • RP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
gene perturbation
0.83
transcription factor binding site profile
0.81
histone modification site profile
0.8
disease perturbation
0.79


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.85   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.85   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nudix hydrolase 19
VGNC:11251
100615341
Mouse
MGI:94203
110959
Rat
RGD:1302935
308518
Dog
nudix hydrolase 19
VGNC:44032
100683930
Cow
nudix hydrolase 19
VGNC:32334
785361
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nudix hydrolase 19
Mouse
Rat
Dog
nudix hydrolase 19
Cow
nudix hydrolase 19
Pathways (7)
Fatty acid metabolism (R-HSA-8978868)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Peroxisomal lipid metabolism
Reactome
Peroxisomal protein import
Name
Explore in Pharos
Explore in Source
Fatty acid metabolism
Metabolism
Metabolism of lipids
Peroxisomal lipid metabolism
Peroxisomal protein import
Gene Ontology Terms (7)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (105)
1 – 10 of 105
HSPD1
Tbio
Novelty: 0.00018924
p_int: 0.999676558
p_ni: 0.000323439
p_wrong: 3e-9
Score: 0.232
Data Source: BioPlex,STRINGDB
BPNT1
Tbio
Family: Enzyme
Novelty: 0.1114547
p_int: 0.98588053
p_ni: 0.01411947
Score: 0.2
Data Source: BioPlex,STRINGDB
SLC25A41
Tdark
Family: Transporter
Novelty: 1.04918395
p_int: 0.97197867
p_ni: 0.027998658
p_wrong: 0.000022671
Data Source: BioPlex
GLB1L3
Tdark
Family: Enzyme
Novelty: 1.00833616
p_int: 0.963412382
p_ni: 0.032679123
p_wrong: 0.003908495
Data Source: BioPlex
YBEY
Tdark
Family: Enzyme
Novelty: 0.02778029
p_int: 0.962412075
p_ni: 0.031510932
p_wrong: 0.006076993
Score: 0.2
Data Source: BioPlex,STRINGDB
NIT1
Tbio
Family: Enzyme
Novelty: 0.00498587
p_int: 0.954868749
p_ni: 0.045105418
p_wrong: 0.000025833
Data Source: BioPlex
DEFA5
Tbio
Novelty: 0.00863727
p_int: 0.941741893
p_ni: 0.058253076
p_wrong: 0.000005031
Data Source: BioPlex
OXLD1
Tdark
Family: Enzyme
Novelty: 23
p_int: 0.913945522
p_ni: 0.042659943
p_wrong: 0.043394535
Data Source: BioPlex
ACSM5
Tbio
Family: Enzyme
Novelty: 0.11562771
p_int: 0.912703227
p_ni: 0.059527071
p_wrong: 0.027769702
Score: 0.213
Data Source: BioPlex,STRINGDB
NUDT7
Tdark
Family: Enzyme
Novelty: 0.05817561
Score: 0.974
Data Source: STRINGDB
Publication Statistics
PubMed Score  2.85

PubMed score by year
PubTator Score  0.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer