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Tdark
CAPN14
Calpain-14

Protein Summary
Description
Calcium-regulated non-lysosomal thiol-protease. Calpains are a family of cytosolic calcium-activated cysteine proteases involved in a variety of cellular processes including apoptosis, cell division, modulation of integrin-cytoskeletal interactions, and synaptic plasticity (Dear et al., 2000 [PubMed 10964513]). CAPN14 belongs to the calpain large subunit family.[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000403897
  • ENSP00000385247
  • ENSG00000214711
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
cell line
0.71
tissue sample
0.62
microRNA
0.56
molecular function
0.49


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.05   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 41   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.05   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 41   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
2.1
77.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2.1
77.7
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calpain 14
VGNC:181
470346
Macaque
calpain 14
707608
Dog
calpain 14
VGNC:38702
483026
Cow
calpain 14
VGNC:26745
515741
Pig
calpain 14 [Source:HGNC Symbol;Acc:HGNC:16664]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calpain 14
Macaque
calpain 14
Dog
calpain 14
Cow
calpain 14
Pig
calpain 14 [Source:HGNC Symbol;Acc:HGNC:16664]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-A8MX76-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (2)
Degradation of the extracellular matrix (R-HSA-1474228)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Degradation of the extracellular matrix
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Degradation of the extracellular matrix
Extracellular matrix organization
Protein-Protein Interactions (55)
1 – 10 of 55
CAST
Tbio
Novelty: 0.00099404
Score: 0.939
Data Source: STRINGDB
CAPNS1
Tbio
Novelty: 0.00954566
Score: 0.923
Data Source: STRINGDB
CAPNS2
Tbio
Novelty: 0.45658116
Score: 0.913
Data Source: STRINGDB
CASP3
Tchem
Family: Enzyme
Novelty: 0.00003555
Score: 0.67
Data Source: STRINGDB
EPC2
Tbio
Novelty: 0.02760809
Score: 0.668
Data Source: STRINGDB
CTSB
Tchem
Family: Enzyme
Novelty: 0.00026238
Score: 0.663
Data Source: STRINGDB
CDH26
Tbio
Novelty: 0.11829125
Score: 0.641
Data Source: STRINGDB
CYCS
Tchem
Novelty: 0.00014004
Score: 0.594
Data Source: STRINGDB
CTSL
Tclin
Family: Enzyme
Novelty: 0.00058727
Score: 0.575
Data Source: STRINGDB
CDK5
Tchem
Family: Kinase
Novelty: 0.00071394
Score: 0.57
Data Source: STRINGDB
Publication Statistics
PubMed Score  12.05

PubMed score by year
PubTator Score  6.11

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer