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Tdark
EFCAB8
EF-hand calcium-binding domain-containing protein 8

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000618684
  • ENSP00000481567
  • ENSG00000215529
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.81
tissue
0.75
disease
0.7
phenotype
0.58
tissue sample
0.48


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.39   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 4   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.39   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 4   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
1
1
1
83.6
lymphocyte count
3
2
3
83
lymphocyte percentage of leukocytes
2
2
2
70.4
cup-to-disc ratio measurement
2
2
2
69.1
mean platelet volume
1
1
1
55.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
1
83.6
lymphocyte count
3
83
lymphocyte percentage of leukocytes
2
70.4
cup-to-disc ratio measurement
2
69.1
mean platelet volume
1
55.2
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Dog
EF-hand calcium binding domain 8
VGNC:54647
102156949
Species
Name
OMA
EggNOG
Inparanoid
Dog
EF-hand calcium binding domain 8
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-A8MWE9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (1)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (8)
1 – 8 of 8
VSTM2L
Tdark
Novelty:  0.43945285
Score:  0.642
Data Source:  STRINGDB
SMIM1
Tbio
Novelty:  0.04077799
Score:  0.497
Data Source:  STRINGDB
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
Score:  0.476
Data Source:  STRINGDB
CSRP2
Tbio
Novelty:  0.04408353
Score:  0.446
Data Source:  STRINGDB
BLCAP
Tbio
Novelty:  0.01612864
Score:  0.445
Data Source:  STRINGDB
GNRH2
Tbio
Novelty:  0.0027348
Score:  0.441
Data Source:  STRINGDB
KCMF1
Tbio
Family:  Enzyme
Novelty:  0.05485534
Score:  0.422
Data Source:  STRINGDB
IL36G
Tbio
Novelty:  0.04034902
Score:  0.414
Data Source:  STRINGDB
Publication Statistics
PubMed Score  0.39

PubMed score by year
PubTator Score  0.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer