Tbio BECN2 Beclin-2

Protein Summary

Description

Involved in 2 distinct lysosomal degradation pathways: acts as a regulator of autophagy and as a regulator of G-protein coupled receptors turnover. Regulates degradation in lysosomes of a variety of G-protein coupled receptors via its interaction with GPRASP1/GASP1.

Uniprot Accession IDs

• A8MW95
• E9KNW0

Gene Name

• BECN2

Ensembl ID

• ENST00000419583
• ENSP00000488361
• ENSG00000196289

Symbol

• BECN1L1
• BECN1P1
• BECN1L1
• BECN1P1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue	0.65
biological process	0.39
cellular component	0.38
biological term	0.33
interacting protein	0.31

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Protease Inhibitor / Beclin-2

DTO Classes

Protein / Enzyme Modulator / Protease Inhibitor / Beclin-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 232   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0