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Tdark
KRTAP9-7
Keratin-associated protein 9-7

Protein Summary
Description
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000391354
  • ENSP00000375149
  • ENSG00000180386
  • ENST00000573531
  • ENSP00000460369
  • ENSG00000262221

Symbol
  • KAP9.7
  • KRTAP9.7
  • KRTAP9L1
  • KAP9.7
  • KRTAP9L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.65
cell line
0.43
cellular component
0.36
tissue
0.16
protein domain
0.15


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.02   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.02   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (71)
1 – 10 of 71
KRTAP20-1
Tdark
Novelty:  0.5308345
Score:  0.578
Data Source:  STRINGDB
KRTAP27-1
Tdark
Novelty:  0.72484342
Score:  0.548
Data Source:  STRINGDB
KRTAP1-4
Tdark
Novelty:  0.44744505
Score:  0.543
Data Source:  STRINGDB
KRTAP10-8
Tdark
Novelty:  6.35380236
Score:  0.542
Data Source:  STRINGDB
KRTAP26-1
Tdark
Novelty:  0.48053029
Score:  0.537
Data Source:  STRINGDB
KRTAP24-1
Tdark
Novelty:  0.3470695
Score:  0.533
Data Source:  STRINGDB
KRTAP19-6
Tdark
Novelty:  69.38557994
Score:  0.53
Data Source:  STRINGDB
KRTAP19-7
Tdark
Novelty:  63.61563518
Score:  0.529
Data Source:  STRINGDB
KRTAP20-3
Tdark
Novelty:  217
Score:  0.527
Data Source:  STRINGDB
KRTAP12-1
Tdark
Novelty:  0.59243755
Score:  0.524
Data Source:  STRINGDB
Pathways (2)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Gene Ontology Terms (3)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
1
1
0
1.1
9.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
1.1
9.6
Publication Statistics
PubMed Score 0.02
PubMed score by year