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Tbio
GNAT3
Guanine nucleotide-binding protein G(t) subunit alpha-3

Protein Summary
Description
Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and increase of intrace ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398291
  • ENSP00000381339
  • ENSG00000214415

Symbol
  • GDCA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
cellular component
0.85
tissue
0.71
cell type or tissue
0.63
interacting protein
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.72   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.72   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
5
5
4
4.2
88.5
mean platelet volume
3
1
3
81.4
high density lipoprotein cholesterol measurement
1
1
1
78.1
aspartate aminotransferase measurement
1
1
1
61
basophil count
2
2
2
57.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
4
4.2
88.5
mean platelet volume
3
81.4
high density lipoprotein cholesterol measurement
1
78.1
aspartate aminotransferase measurement
1
61
basophil count
2
57.1
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein subunit alpha transducin 3
VGNC:8680
472426
Mouse
MGI:3588268
242851
Rat
RGD:727817
286924
Dog
G protein subunit alpha transducin 3
VGNC:41309
491406
Horse
G protein subunit alpha transducin 3
VGNC:18421
100049917
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein subunit alpha transducin 3
Mouse
Rat
Dog
G protein subunit alpha transducin 3
Horse
G protein subunit alpha transducin 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-A8MTJ3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (33)
ADP signalling through P2Y purinoceptor 12 (R-HSA-392170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 31
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ADP signalling through P2Y purinoceptor 12
Reactome
Activation of GABAB receptors
Reactome
Adenylate cyclase inhibitory pathway
Reactome
Chaperonin-mediated protein folding
Reactome
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Name
Explore in Pharos
Explore in Source
ADP signalling through P2Y purinoceptor 12
Activation of GABAB receptors
Adenylate cyclase inhibitory pathway
Chaperonin-mediated protein folding
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Gene Ontology Terms (21)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (339)
1 – 10 of 339
GNAI1
Tbio
Novelty:  0.0488971
p_int:  0.999995297
p_ni:  0.000003713
p_wrong:  9.9e-7
Score:  0.93
Data Source:  BioPlex,STRINGDB
RAB5C
Tbio
Family:  Enzyme
Novelty:  0.02952779
p_int:  0.997214725
p_ni:  0.00019126
p_wrong:  0.002594015
Score:  0.5
Data Source:  BioPlex,STRINGDB
TAS1R2
Tbio
Family:  GPCR
Novelty:  0.00568766
Score:  0.99
Data Source:  STRINGDB
TAS1R3
Tbio
Family:  GPCR
Novelty:  0.00370936
Score:  0.99
Data Source:  STRINGDB
GNB1
Tbio
Novelty:  0.02477955
Score:  0.984
Data Source:  Reactome,STRINGDB
PLCB2
Tbio
Family:  Enzyme
Novelty:  0.00571285
Score:  0.982
Data Source:  STRINGDB
TAS1R1
Tbio
Family:  GPCR
Novelty:  0.00913004
Score:  0.982
Data Source:  STRINGDB
TAS2R10
Tchem
Family:  GPCR
Novelty:  0.07564224
Score:  0.979
Data Source:  STRINGDB
TAS2R4
Tchem
Family:  GPCR
Novelty:  0.02938385
Score:  0.979
Data Source:  STRINGDB
GNB4
Tbio
Novelty:  0.08250797
Score:  0.978
Data Source:  STRINGDB
Publication Statistics
PubMed Score  142.72

PubMed score by year
PubTator Score  17.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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