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Tdark
NEURL1B
E3 ubiquitin-protein ligase NEURL1B

Protein Summary
Description
E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369800
  • ENSP00000358815
  • ENSG00000214357
  • ENST00000520919
  • ENSP00000429797
  • ENST00000522853
  • ENSP00000430001

Symbol
  • NEURL3
  • neur2
  • NEURL3
  • RNF67B
  • hNeur2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.76
microRNA
0.71
pathway
0.62
PubMedID
0.6
tissue sample
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.55   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 41   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.55   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 41   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
3
3
86.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
86.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neuralized E3 ubiquitin protein ligase 1B
VGNC:4098
462362
Macaque
neuralized E3 ubiquitin protein ligase 1B
709907
Mouse
MGI:3643092
240055
Rat
RGD:1564984
303019
Dog
neuralized E3 ubiquitin protein ligase 1B
VGNC:49893
489118
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neuralized E3 ubiquitin protein ligase 1B
Macaque
neuralized E3 ubiquitin protein ligase 1B
Mouse
Rat
Dog
neuralized E3 ubiquitin protein ligase 1B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-A8MQ27-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (18)
Activated NOTCH1 Transmits Signal to the Nucleus (R-HSA-2122948)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NOTCH1 Transmits Signal to the Nucleus
Reactome
Constitutive Signaling by NOTCH1 HD Domain Mutants
Reactome
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Reactome
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 HD Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Disease
Gene Ontology Terms (7)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (57)
1 – 10 of 57
DLL1
Tbio
Novelty: 0.00150384
Score: 0.972
Data Source: STRINGDB
DLL4
Tbio
Novelty: 0.00263355
Score: 0.971
Data Source: STRINGDB
JAG2
Tbio
Novelty: 0.00176158
Score: 0.967
Data Source: STRINGDB
JAG1
Tbio
Novelty: 0.00107618
Score: 0.96
Data Source: STRINGDB
NOTCH1
Tchem
Novelty: 0.00012547
Score: 0.952
Data Source: STRINGDB
NOTCH3
Tchem
Novelty: 0.000953
Score: 0.942
Data Source: STRINGDB
NOTCH2
Tchem
Novelty: 0.00195617
Score: 0.942
Data Source: STRINGDB
UBC
Tbio
Novelty: 0.00204643
Score: 0.901
Data Source: STRINGDB
UBB
Tbio
Novelty: 0.00661254
Score: 0.901
Data Source: STRINGDB
UBA52
Tbio
Novelty: 0.01637744
Score: 0.9
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.55

PubMed score by year
PubTator Score  1.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer