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Tbio
GABRR3
Gamma-aminobutyric acid receptor subunit rho-3

Protein Classes
Protein Summary
Description
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. The neurotransmitter gamma-aminobutyric acid (GABA) functions in the central nervous system to regulate synaptic transmission of neurons. This gene encodes one of three related subunits, which combine as homo- or hetero-pentamers to form GABA(C) receptors. In humans, some individuals contain a single-base polymorphism (dbSNP rs832032) that is predicted to inactivate the gene product. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000472788
  • ENSP00000420790
  • ENSG00000183185
  • ENST00000621172
  • ENSP00000481321
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
drug
0.75
protein domain
0.73
tissue
0.59
cellular component
0.57


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.56   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 48   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.56   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 48   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
gamma-aminobutyric acid type A receptor rho3 subunit
698660
Mouse
MGI:3588203
328699
Rat
RGD:621564
192258
Horse
gamma-aminobutyric acid type A receptor rho3 subunit
100072537
Cow
gamma-aminobutyric acid type A receptor rho3 subunit
VGNC:53569
520166
Species
Name
OMA
EggNOG
Inparanoid
Macaque
gamma-aminobutyric acid type A receptor rho3 subunit
Mouse
Rat
Horse
gamma-aminobutyric acid type A receptor rho3 subunit
Cow
gamma-aminobutyric acid type A receptor rho3 subunit
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-A8MPY1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)
GABA receptor activation (R-HSA-977443)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
GABA receptor activation
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Reactome
Transmission across Chemical Synapses
Name
Explore in Pharos
Explore in Source
GABA receptor activation
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Transmission across Chemical Synapses
Protein-Protein Interactions (255)
1 – 10 of 255
GABBR1
Tclin
Family: GPCR
Novelty: 0.00086493
Score: 0.895
Data Source: STRINGDB
GAD1
Tbio
Family: Enzyme
Novelty: 0.00067443
Score: 0.839
Data Source: STRINGDB
SLC6A1
Tclin
Family: Transporter
Novelty: 0.00165116
Score: 0.832
Data Source: STRINGDB
GABBR2
Tclin
Family: GPCR
Novelty: 0.00739771
Score: 0.828
Data Source: STRINGDB
GABRR1
Tchem
Family: IC
Novelty: 0.01601481
Score: 0.804
Data Source: Reactome,STRINGDB
GABRR2
Tbio
Family: IC
Novelty: 0.01651914
Score: 0.804
Data Source: Reactome,STRINGDB
GAD2
Tbio
Family: Enzyme
Novelty: 0.00058427
Score: 0.801
Data Source: STRINGDB
PVALB
Tbio
Novelty: 0.00024439
Score: 0.793
Data Source: STRINGDB
HTR7
Tclin
Family: GPCR
Novelty: 0.00169884
Score: 0.789
Data Source: STRINGDB
GPHN
Tbio
Novelty: 0.0020752
Score: 0.775
Data Source: STRINGDB
Publication Statistics
PubMed Score  50.56

PubMed score by year
PubTator Score  48.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer