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Tdark
SFI1
Protein SFI1 homolog

Protein Summary
Description
Plays a role in the dynamic structure of centrosome-associated contractile fibers via its interaction with CETN2.
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.88
transcription factor perturbation
0.74
interacting protein
0.73
transcription factor
0.69
PubMedID
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.51   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 42   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.51   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
1
2
45.9
1
1
0
1.1
43.3
1
1
0
1.2
31.6
Cleft palate
1
1
0
1.2
31.6
neutrophil percentage of leukocytes
1
1
1
15.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
45.9
0
1.1
43.3
0
1.2
31.6
Cleft palate
0
1.2
31.6
neutrophil percentage of leukocytes
1
15.1
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (17)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (153)
1 – 10 of 153
CETN1
Tbio
Novelty: 0.01208917
p_int: 0.999999994
p_wrong: 6e-9
Score: 0.925
Data Source: BioPlex,STRINGDB
CETN2
Tbio
Novelty: 0.00641301
Score: 0.997
Data Source: STRINGDB
TUBGCP2
Tbio
Novelty: 0.01856674
Score: 0.971
Data Source: STRINGDB
TUBGCP3
Tbio
Novelty: 0.0221126
Score: 0.964
Data Source: STRINGDB
CETN3
Tbio
Novelty: 0.00705513
Score: 0.963
Data Source: STRINGDB
PLK4
Tchem
Family: Kinase
Novelty: 0.00265851
Score: 0.953
Data Source: STRINGDB
PLK1
Tchem
Family: Kinase
Novelty: 0.00062799
Score: 0.95
Data Source: STRINGDB
MZT1
Tdark
Novelty: 0.06713659
Score: 0.947
Data Source: STRINGDB
CCP110
Tbio
Novelty: 0.02399511
Score: 0.939
Data Source: STRINGDB
CDK1
Tchem
Family: Kinase
Novelty: 0.00040776
Score: 0.932
Data Source: STRINGDB
Publication Statistics
PubMed Score  56.51

PubMed score by year
PubTator Score  9.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer