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Tdark
SFI1
Protein SFI1 homolog

Protein Summary
Description
Plays a role in the dynamic structure of centrosome-associated contractile fibers via its interaction with CETN2.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000400288
  • ENSP00000383145
  • ENSG00000198089
  • ENST00000400289
  • ENSP00000383146
  • ENST00000432498
  • ENSP00000402679
  • ENST00000540643
  • ENSP00000443025

Symbol
  • KIAA0542
  • PISD
  • hSfi1p
  • PPP1R139
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.88
transcription factor perturbation
0.74
interacting protein
0.73
transcription factor
0.69
PubMedID
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
View Data
 GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.51   (req: < 5)
View Publications
Gene RIFs: 3   (req: <= 3)
View Gene RIFs
Antibodies: 42   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.51   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
EFO_0004587
2
1
2
45.9
type II diabetes mellitus
EFO_0001360
1
1
0
1.1
43.3
cleft lip
EFO_0003959
1
1
0
1.2
31.6
Cleft palate
HP_0000175
1
1
0
1.2
31.6
neutrophil percentage of leukocytes
EFO_0007990
1
1
1
15.1
Items per page:
1 – 5 of 6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
EFO_0004587
2
45.9
type II diabetes mellitus
EFO_0001360
0
1.1
43.3
cleft lip
EFO_0003959
0
1.2
31.6
Cleft palate
HP_0000175
0
1.2
31.6
neutrophil percentage of leukocytes
EFO_0007990
1
15.1
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SFI1 centrin binding protein
VGNC:6012
458771
Macaque
SFI1 centrin binding protein
716833
Mouse
Sfi1 homolog, spindle assembly associated (yeast)
MGI:1926137
78887
Rat
SFI1 centrin binding protein
RGD:1560636
305467
Dog
SFI1 centrin binding protein
VGNC:46075
486367
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SFI1 centrin binding protein
Macaque
SFI1 centrin binding protein
Mouse
Sfi1 homolog, spindle assembly associated (yeast)
Rat
SFI1 centrin binding protein
Dog
SFI1 centrin binding protein
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (17)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
72 targets
R-HSA-8854518
Reactome
Anchoring of the basal body to the plasma membrane
97 targets
R-HSA-5620912
Reactome
Cell Cycle
597 targets
R-HSA-1640170
Reactome
Cell Cycle, Mitotic
495 targets
R-HSA-69278
Reactome
Centrosome maturation
81 targets
R-HSA-380287
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
72 targets
R-HSA-8854518
Anchoring of the basal body to the plasma membrane
97 targets
R-HSA-5620912
Cell Cycle
597 targets
R-HSA-1640170
Cell Cycle, Mitotic
495 targets
R-HSA-69278
Centrosome maturation
81 targets
R-HSA-380287
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
phosphatase binding
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (153)
1 – 10 of 153
CETN1
Tbio
Novelty: 0.01208917
p_int: 0.999999994
p_wrong: 6e-9
Score: 0.925
Data Source: BioPlex,STRINGDB
CETN2
Tbio
Novelty: 0.00641301
Score: 0.997
Data Source: STRINGDB
TUBGCP2
Tbio
Novelty: 0.01856674
Score: 0.971
Data Source: STRINGDB
TUBGCP3
Tbio
Novelty: 0.0221126
Score: 0.964
Data Source: STRINGDB
CETN3
Tbio
Novelty: 0.00705513
Score: 0.963
Data Source: STRINGDB
PLK4
Tchem
Family: Kinase
Novelty: 0.00265851
Score: 0.953
Data Source: STRINGDB
PLK1
Tchem
Family: Kinase
Novelty: 0.00062799
Score: 0.95
Data Source: STRINGDB
MZT1
Tdark
Novelty: 0.06713659
Score: 0.947
Data Source: STRINGDB
CCP110
Tbio
Novelty: 0.02399511
Score: 0.939
Data Source: STRINGDB
CDK1
Tchem
Family: Kinase
Novelty: 0.00040776
Score: 0.932
Data Source: STRINGDB
Publication Statistics
PubMed Score  56.51

PubMed score by year
PubTator Score  9.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer