Tdark SFI1 Protein SFI1 homolog

Protein Summary

Description

Plays a role in the dynamic structure of centrosome-associated contractile fibers via its interaction with CETN2.

Uniprot Accession IDs

• A8K8P3
• A1L373
• A1L387
• A2A2L2
• B1AKL9
• B5MDB7
• B7Z1V6
• B7Z8G3
• B7ZBE2
• B7ZBE3
• O60289
• Q2TAN8
• Q5W1B5
• Q86TK0
• Q8N4U8
• Q8N8C1
• Q8WU14
• hSFI1

Gene Name

• SFI1

Ensembl ID

• ENST00000400288
• ENSP00000383145
• ENSG00000198089
• ENST00000400289
• ENSP00000383146
• ENST00000432498
• ENSP00000402679
• ENST00000540643
• ENSP00000443025

Symbol

• KIAA0542
• PISD
• hSfi1p
• PPP1R139

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.88
transcription factor perturbation	0.74
interacting protein	0.73
transcription factor	0.69
PubMedID	0.67

IDG Partner Tools

GlyGen

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.51   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 42   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.51   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (6)

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
lymphocyte count	EFO_0004587	2	1	2		45.9
type II diabetes mellitus	EFO_0001360	1	1	0	1.1	43.3
cleft lip	EFO_0003959	1	1	0	1.2	31.6
Cleft palate	HP_0000175	1	1	0	1.2	31.6
neutrophil percentage of leukocytes	EFO_0007990	1	1	1		15.1

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
lymphocyte count	EFO_0004587	2		45.9
type II diabetes mellitus	EFO_0001360	0	1.1	43.3
cleft lip	EFO_0003959	0	1.2	31.6
Cleft palate	HP_0000175	0	1.2	31.6
neutrophil percentage of leukocytes	EFO_0007990	1		15.1

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Protein Data Bank (1)

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (17)

Reactome (16)

PathwayCommons (1)

AURKA Activation by TPX2 (R-HSA-8854518)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	AURKA Activation by TPX2	72 targets	R-HSA-8854518
Reactome	Anchoring of the basal body to the plasma membrane	97 targets	R-HSA-5620912
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle, Mitotic	495 targets	R-HSA-69278
Reactome	Centrosome maturation	81 targets	R-HSA-380287

Name	Explore in Pharos	Explore in Source
AURKA Activation by TPX2	72 targets	R-HSA-8854518
Anchoring of the basal body to the plasma membrane	97 targets	R-HSA-5620912
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle, Mitotic	495 targets	R-HSA-69278
Centrosome maturation	81 targets	R-HSA-380287

Gene Ontology Terms (8)

Functions (1)

Components (3)

Processes (4)

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GO Term	Evidence	Assigned by
phosphatase binding	Inferred from Direct Assay (IDA)	UniProtKB

Protein-Protein Interactions (153)

Explore Interacting Targets

1 – 10 of 153

• See Interactions on String-DB

CETN1

Tbio

Novelty: 0.01208917

p_int: 0.999999994

p_wrong: 6e-9

Score: 0.925

Data Source: BioPlex,STRINGDB

CETN2

Tbio

Novelty: 0.00641301

Score: 0.997

Data Source: STRINGDB

TUBGCP2

Tbio

Novelty: 0.01856674

Score: 0.971

Data Source: STRINGDB

TUBGCP3

Tbio

Novelty: 0.0221126

Score: 0.964

Data Source: STRINGDB

CETN3

Tbio

Novelty: 0.00705513

Score: 0.963

Data Source: STRINGDB

PLK4

Tchem

Family: Kinase

Novelty: 0.00265851

Score: 0.953

Data Source: STRINGDB

PLK1

Tchem

Family: Kinase

Novelty: 0.00062799

Score: 0.95

Data Source: STRINGDB

MZT1

Tdark

Novelty: 0.06713659

Score: 0.947

Data Source: STRINGDB

CCP110

Tbio

Novelty: 0.02399511

Score: 0.939

Data Source: STRINGDB

CDK1

Tchem

Family: Kinase

Novelty: 0.00040776

Score: 0.932

Data Source: STRINGDB

Publication Statistics

PubMed Score  56.51

PubMed score by year

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PubTator Score  9.36

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Cytoskeleton
Polymorphism
Reference proteome
Repeat

GWAS Trait Find Similar Targets

cleft lip
Cleft palate
lymphocyte count
monocyte count
neutrophil percentage of leukocytes
type II diabetes mellitus