Tdark SFI1 Protein SFI1 homolog

Protein Summary

Description

Plays a role in the dynamic structure of centrosome-associated contractile fibers via its interaction with CETN2.

Uniprot Accession IDs

• A8K8P3
• A1L373
• A1L387
• A2A2L2
• B1AKL9
• B5MDB7
• B7Z1V6
• B7Z8G3
• B7ZBE2
• B7ZBE3
• O60289
• Q2TAN8
• Q5W1B5
• Q86TK0
• Q8N4U8
• Q8N8C1
• Q8WU14
• hSFI1

Gene Name

• SFI1

Ensembl ID

• ENST00000400288
• ENSP00000383145
• ENSG00000198089
• ENST00000400289
• ENSP00000383146
• ENST00000432498
• ENSP00000402679
• ENST00000540643
• ENSP00000443025

Symbol

• KIAA0542
• PISD
• hSfi1p
• PPP1R139

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.88
transcription factor perturbation	0.74
interacting protein	0.73
transcription factor	0.69
PubMedID	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.23   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 42   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.23   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0