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Tdark
EFCAB7
EF-hand calcium-binding domain-containing protein 7

Protein Summary
Description
Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Required for the localization of the EVC2:EVC subcomplex at the base of primary cilia.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371088
  • ENSP00000360129
  • ENSG00000203965

Symbol
  • KIAA1799
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
gene perturbation
0.59
transcription factor binding site profile
0.59
cell line
0.57
tissue sample
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.58   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.58   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (60)
1 – 10 of 60
SPA17
Tbio
Novelty:  0.02632554
p_int:  0.999999904
p_ni:  7e-8
p_wrong:  2.5e-8
Score:  0.827
Data Source:  BioPlex,STRINGDB
NRGN
Tbio
Novelty:  0.00352757
p_int:  0.999999255
p_ni:  1.93e-7
p_wrong:  5.52e-7
Score:  0.218
Data Source:  BioPlex,STRINGDB
MYL12B
Tbio
Novelty:  0.00999083
p_int:  0.999998136
p_ni:  0.000001737
p_wrong:  1.28e-7
Data Source:  BioPlex
TTC23L
Tdark
Novelty:  0.36199095
p_int:  0.99999805
p_ni:  0.000001914
p_wrong:  3.5e-8
Score:  0.534
Data Source:  BioPlex,STRINGDB
RNF34
Tbio
Family:  Enzyme
Novelty:  0.04365307
p_int:  0.999694542
p_ni:  0.00030545
p_wrong:  7e-9
Score:  0.251
Data Source:  BioPlex,STRINGDB
AKAP14
Tbio
Family:  Enzyme
Novelty:  0.50699923
p_int:  0.93824093
p_ni:  0.000440484
p_wrong:  0.061318585
Score:  0.737
Data Source:  BioPlex,STRINGDB
RFFL
Tbio
Family:  Enzyme
Novelty:  0.06621524
p_int:  0.928757719
p_ni:  0.000497005
p_wrong:  0.070745276
Score:  0.319
Data Source:  BioPlex,STRINGDB
IQCE
Tdark
Novelty:  0.24800472
Score:  0.987
Data Source:  Reactome,STRINGDB
EVC2
Tbio
Novelty:  0.01398469
Score:  0.958
Data Source:  Reactome,STRINGDB
EVC
Tbio
Novelty:  0.02171391
Score:  0.952
Data Source:  Reactome,STRINGDB
Pathways (6)
Activation of SMO (R-HSA-5635838)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of SMO
Reactome
Hedgehog 'on' state
Reactome
Signal Transduction
Reactome
Signaling by Hedgehog
Name
Explore in Pharos
Explore in Source
Activation of SMO
Hedgehog 'on' state
Signal Transduction
Signaling by Hedgehog
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
2
1.1
69.6
mean corpuscular volume
1
1
1
55.2
1
1
0
1.2
44.2
mean reticulocyte volume
1
1
1
35
serum gamma-glutamyl transferase measurement
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.1
69.6
mean corpuscular volume
1
55.2
0
1.2
44.2
mean reticulocyte volume
1
35
serum gamma-glutamyl transferase measurement
1
31.4
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
EF-hand calcium binding domain 7
VGNC:1234
456907
Macaque
EF-hand calcium binding domain 7
696830
Mouse
MGI:2385199
230500
Rat
RGD:1561825
362549
Dog
EF-hand calcium binding domain 7
VGNC:40218
479546
Species
Name
OMA
EggNOG
Inparanoid
Chimp
EF-hand calcium binding domain 7
Macaque
EF-hand calcium binding domain 7
Mouse
Rat
Dog
EF-hand calcium binding domain 7
Publication Statistics
PubMed Score 2.58
PubMed score by year
PubTator Score 1.03
PubTator score by year