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Tbio
CLCA1
Calcium-activated chloride channel regulator 1

Protein Summary
Description
May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC. This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000234701
  • ENSP00000234701
  • ENSG00000016490
  • ENST00000394711
  • ENSP00000378200

Symbol
  • CACC1
  • CACC
  • GOB5
  • CACC1
  • CLCRG1
  • CaCC-1
  • hCLCA1
  • hCaCC-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
molecular function
0.88
cell type or tissue
0.8
cell line
0.72
cellular component
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.99   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 190   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.99   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (77)
CLCA4
Tbio
Family:  IC
Novelty:  0.05891943
Score:  0.92
Data Source:  STRINGDB
CLCA2
Tbio
Family:  IC
Novelty:  0.0306541
Score:  0.907
Data Source:  STRINGDB
IL13
Tbio
Novelty:  0.00021435
Score:  0.794
Data Source:  STRINGDB
SERPINB2
Tbio
Novelty:  0.00204345
Score:  0.748
Data Source:  STRINGDB
SLC13A2
Tbio
Family:  Transporter
Novelty:  0.01020451
Score:  0.748
Data Source:  STRINGDB
POSTN
Tbio
Novelty:  0.00108629
Score:  0.741
Data Source:  STRINGDB
MUC5AC
Tbio
Novelty:  0.00074159
Score:  0.74
Data Source:  STRINGDB
SI
Tchem
Family:  Enzyme
Novelty:  0.00048694
Score:  0.726
Data Source:  STRINGDB
FKBP5
Tchem
Family:  Enzyme
Novelty:  0.00214511
Score:  0.714
Data Source:  STRINGDB
FKBP4
Tchem
Family:  Enzyme
Novelty:  0.0023525
Score:  0.712
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Hallux valgus
1
1
0
2.1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Hallux valgus
0
2.1
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chloride channel accessory 1
VGNC:500
456640
Macaque
chloride channel accessory 1
574295
Mouse
MGI:1346342
23844
Rat
RGD:1306258
308015
Dog
chloride channel accessory 1
VGNC:39296
490178
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chloride channel accessory 1
Macaque
chloride channel accessory 1
Mouse
Rat
Dog
chloride channel accessory 1
Publication Statistics
PubMed Score 99.99
PubMed score by year
PubTator Score 108.58
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title