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Tbio
CD300LB
CMRF35-like molecule 7

Protein Summary
Description
Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2. CD300LB is a nonclassical activating receptor of the immunoglobulin (Ig) superfamily expressed on myeloid cells (Martinez-Barriocanal and Sayos, 2006 [PubMed 16920917]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000392621
  • ENSP00000376397
  • ENSG00000178789

Symbol
  • CD300B
  • CLM7
  • CMRF35A2
  • IREM3
  • LMIR5
  • TREM5
  • CLM7
  • CLM-7
  • IREM3
  • TREM5
  • CD300b
  • IREM-3
  • TREM-5
  • CMRF35-A2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.64
cell type or tissue
0.58
protein domain
0.58
gene perturbation
0.5
cell line
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.04   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.04   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (103)
TYROBP
Tbio
Family:  Enzyme
Novelty:  0.00410031
Score:  0.995
Data Source:  Reactome,STRINGDB
GRB2
Tchem
Novelty:  0.00091605
Score:  0.857
Data Source:  STRINGDB
HCST
Tbio
Novelty:  0.01604587
Score:  0.714
Data Source:  STRINGDB
TIMD4
Tbio
Novelty:  0.00854723
Score:  0.699
Data Source:  STRINGDB
FCER1G
Tbio
Novelty:  0.00783146
Score:  0.669
Data Source:  STRINGDB
LILRA1
Tdark
Novelty:  0.17371827
Score:  0.669
Data Source:  STRINGDB
TREM1
Tbio
Novelty:  0.00249253
Score:  0.652
Data Source:  STRINGDB
SIGLEC15
Tbio
Novelty:  0.04928596
Score:  0.64
Data Source:  STRINGDB
CLEC5A
Tbio
Novelty:  0.01710591
Score:  0.625
Data Source:  STRINGDB
TREML1
Tbio
Novelty:  0.03513416
Score:  0.615
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
DAP12 interactions
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
DAP12 interactions
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Innate Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
1
1
70.5
monocyte percentage of leukocytes
1
1
1
14
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
70.5
monocyte percentage of leukocytes
1
14
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD300 molecule like family member b
VGNC:9175
468319
Mouse
MGI:2685099
217304
Rat
RGD:1583718
501738
Dog
CMRF35-like molecule 7
100686711
Cow
CD300 molecule-like family member b
789755
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD300 molecule like family member b
Mouse
Rat
Dog
CMRF35-like molecule 7
Cow
CD300 molecule-like family member b
Publication Statistics
PubMed Score 12.04
PubMed score by year
PubTator Score 4.66
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title