Tdark POM121C Nuclear envelope pore membrane protein POM 121C

Protein Summary

Description

Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL).

Uniprot Accession IDs

• A8CG34
• A0A075B7F8
• A0A087WY75
• O75115
• Q9Y2N3
• Q9Y4S7

Gene Name

• POM121C

Ensembl ID

• ENST00000607367
• ENSP00000476236
• ENSG00000272391
• ENST00000615331
• ENSP00000481575

Symbol

• POM121-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.8
histone modification site profile	0.71
cell line	0.69
tissue sample	0.68
microRNA	0.59

Protein Classes

PANTHER Classes

Protein / Structural Protein / Nuclear Envelope Pore Membrane Protein Pom 121c

Protein / Nucleic Acid Binding / Rna Binding Protein / Nuclear Envelope Pore Membrane Protein Pom 121c

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Nuclear Envelope Pore Membrane Protein Pom 121c

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.45   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.45   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0