ARHGAP32
Rho GTPase-activating protein 32
Protein Summary
GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). RICS is a neuron-associated GTPase-activating protein that may regulate dendritic spine morphology and strength by modulating Rho GTPase (see RHOA; MIM 165390) activity (Okabe et al., 2003 [PubMed 12531901]).[supplied by OMIM, Mar 2008]
- ENST00000310343
- ENSP00000310561
- ENSG00000134909
- ENST00000392657
- ENSP00000376425
- ENST00000527272
- ENSP00000432862
- GRIT
- KIAA0712
- RICS
- GRIT
- RICS
- GC-GAP
- PX-RICS
- p250GAP
- p200RhoGAP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
hub protein | 0.95 | ||
virus perturbation | 0.83 | ||
cellular component | 0.74 | ||
microRNA | 0.69 | ||
cell line | 0.59 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 29.83 (req: < 5)
Gene RIFs: 15 (req: <= 3)
Antibodies: 77 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 29.83 (req: >= 5)
Gene RIFs: 15 (req: > 3)
Antibodies: 77 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (85)
ASB3
Novelty: 0.15921018
p_int: 0.95648777
p_ni: 7.19e-7
p_wrong: 0.043511511
Score: 0.325
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (31)
Reactome (3)
PathwayCommons (4)
WikiPathways (24)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Rho GTPase cycle | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by Rho GTPases | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Rho GTPase cycle | ||||
Signal Transduction | ||||
Signaling by Rho GTPases | ||||
Viral Interactions (0)
Gene Ontology Terms (17)
Functions (2)
Components (13)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
3 | 2 | 0 | 1.1 | 85.1 | |||||
1 | 1 | 0 | 43.6 | 77.9 | |||||
mean platelet volume | 2 | 2 | 2 | 55.1 | |||||
electrocardiography | 1 | 1 | 12 | 28.1 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.1 | 85.1 | |||||
0 | 43.6 | 77.9 | |||||
mean platelet volume | 2 | 55.1 | |||||
electrocardiography | 12 | 28.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | Rho GTPase activating protein 32 | VGNC:3210 | 451663 | |||||
Macaque | Rho GTPase activating protein 32 | 718464 | ||||||
Mouse | MGI:2450166 | 330914 | ||||||
Rat | RGD:1305267 | 315530 | ||||||
Dog | Rho GTPase activating protein 32 | VGNC:38059 | 489283 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | Rho GTPase activating protein 32 | |||||
Macaque | Rho GTPase activating protein 32 | |||||
Mouse | ||||||
Rat | ||||||
Dog | Rho GTPase activating protein 32 | |||||
Publication Statistics
PubMed Score 29.83
PubMed score by year
PubTator Score 42.30
PubTator score by year
Related Publications
Text Mined References (22)
GeneRif Annotations (15)
Items per page:
0 of 0
PMID | Year | Title |
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