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Tbio
ARHGAP32
Rho GTPase-activating protein 32

Protein Summary
Description
GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). RICS is a neuron-associated GTPase-activating protein that may regulate dendritic spine morphology and strength by modulating Rho GTPase (see RHOA; MIM 165390) activity (Okabe et al., 2003 [PubMed 12531901]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310343
  • ENSP00000310561
  • ENSG00000134909
  • ENST00000392657
  • ENSP00000376425
  • ENST00000527272
  • ENSP00000432862

Symbol
  • GRIT
  • KIAA0712
  • RICS
  • GRIT
  • RICS
  • GC-GAP
  • PX-RICS
  • p250GAP
  • p200RhoGAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.95
virus perturbation
0.83
cellular component
0.74
microRNA
0.69
cell line
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.83   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 77   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.83   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (85)
ASB3
Tbio
Novelty:  0.15921018
p_int:  0.95648777
p_ni:  7.19e-7
p_wrong:  0.043511511
Score:  0.325
Data Source:  BioPlex,STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.971
Data Source:  STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
Score:  0.959
Data Source:  STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.959
Data Source:  STRINGDB
NTRK1
Tclin
Family:  Kinase
Novelty:  0.00033453
Score:  0.957
Data Source:  STRINGDB
RHOD
Tbio
Family:  Enzyme
Novelty:  0.0029764
Score:  0.94
Data Source:  STRINGDB
RAC3
Tbio
Family:  Enzyme
Novelty:  0.02125361
Score:  0.939
Data Source:  STRINGDB
RHOJ
Tbio
Family:  Enzyme
Novelty:  0.01217051
Score:  0.933
Data Source:  STRINGDB
RAC2
Tbio
Family:  Enzyme
Novelty:  0.00116234
Score:  0.933
Data Source:  STRINGDB
RHOU
Tbio
Family:  Enzyme
Novelty:  0.01456329
Score:  0.93
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (31)
Rho GTPase cycle (R-HSA-194840)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
Rho GTPase cycle
Signal Transduction
Signaling by Rho GTPases
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
0
1.1
85.1
1
1
0
43.6
77.9
mean platelet volume
2
2
2
55.1
electrocardiography
1
1
12
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
85.1
0
43.6
77.9
mean platelet volume
2
55.1
electrocardiography
12
28.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rho GTPase activating protein 32
VGNC:3210
451663
Macaque
Rho GTPase activating protein 32
718464
Mouse
MGI:2450166
330914
Rat
RGD:1305267
315530
Dog
Rho GTPase activating protein 32
VGNC:38059
489283
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rho GTPase activating protein 32
Macaque
Rho GTPase activating protein 32
Mouse
Rat
Dog
Rho GTPase activating protein 32
Publication Statistics
PubMed Score 29.83
PubMed score by year
PubTator Score 42.30
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title