Tbio ARHGAP32 Rho GTPase-activating protein 32

Protein Summary

Description

GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). RICS is a neuron-associated GTPase-activating protein that may regulate dendritic spine morphology and strength by modulating Rho GTPase (see RHOA; MIM 165390) activity (Okabe et al., 2003 [PubMed 12531901]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• A7KAX9
• I7H0B0
• O94820
• Q86YL6
• Q8IUG4
• Q9BWG3

Gene Name

• ARHGAP32

Ensembl ID

• ENST00000310343
• ENSP00000310561
• ENSG00000134909
• ENST00000392657
• ENSP00000376425
• ENST00000527272
• ENSP00000432862

Symbol

• GRIT
• KIAA0712
• RICS
• GRIT
• RICS
• GC-GAP
• PX-RICS
• p250GAP
• p200RhoGAP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.95
virus perturbation	0.83
cellular component	0.74
microRNA	0.69
cell line	0.59

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.83   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 77   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.83   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (4)

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1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
atrial fibrillation	EFO_0000275	3	2	0	1.1	85.1
brain aneurysm	EFO_0003870	1	1	0	43.6	77.9
mean platelet volume	EFO_0004584	2	2	2		55.1
electrocardiography	EFO_0004327	1	1	12		28.1

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
atrial fibrillation	EFO_0000275	0	1.1	85.1
brain aneurysm	EFO_0003870	0	43.6	77.9
mean platelet volume	EFO_0004584	2		55.1
electrocardiography	EFO_0004327	12		28.1

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Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	Rho GTPase activating protein 32	VGNC:3210	451663
Macaque	Rho GTPase activating protein 32		718464
Mouse	Rho GTPase activating protein 32	MGI:2450166	330914
Rat	Rho GTPase activating protein 32	RGD:1305267	315530
Dog	Rho GTPase activating protein 32	VGNC:38059	489283

Species	Name	OMA	EggNOG	Inparanoid
Chimp	Rho GTPase activating protein 32
Macaque	Rho GTPase activating protein 32
Mouse	Rho GTPase activating protein 32
Rat	Rho GTPase activating protein 32
Dog	Rho GTPase activating protein 32

Protein Structure (1 Structure, 1 AlphaFold Model)

tutorial

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-A7KAX9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (31)

Reactome (3)

PathwayCommons (4)

WikiPathways (24)

Rho GTPase cycle (R-HSA-194840)

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Find Similar Targets

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1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Rho GTPase cycle	139 targets	R-HSA-194840
Reactome	Signal Transduction	2704 targets	R-HSA-162582
Reactome	Signaling by Rho GTPases	402 targets	R-HSA-194315

Name	Explore in Pharos	Explore in Source
Rho GTPase cycle	139 targets	R-HSA-194840
Signal Transduction	2704 targets	R-HSA-162582
Signaling by Rho GTPases	402 targets	R-HSA-194315

Gene Ontology Terms (17)

Functions (2)

Components (13)

Processes (2)

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1 – 2 of 2

GO Term	Evidence	Assigned by
GTPase activator activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
phosphatidylinositol binding	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (85)

Explore Interacting Targets

1 – 10 of 85

• See Interactions on String-DB

ASB3

Tbio

Novelty:  0.15921018

p_int:  0.95648777

p_ni:  7.19e-7

p_wrong:  0.043511511

Score:  0.325

Data Source:  BioPlex,STRINGDB

CDC42

Tchem

Family:  Enzyme

Novelty:  0.00032619

Score:  0.971

Data Source:  STRINGDB

RAC1

Tbio

Family:  Enzyme

Novelty:  0.00365325

Score:  0.959

Data Source:  STRINGDB

RHOA

Tbio

Family:  Enzyme

Novelty:  0.00022204

Score:  0.959

Data Source:  STRINGDB

NTRK1

Tclin

Family:  Kinase

Novelty:  0.00033453

Score:  0.957

Data Source:  STRINGDB

RHOD

Tbio

Family:  Enzyme

Novelty:  0.0029764

Score:  0.94

Data Source:  STRINGDB

RAC3

Tbio

Family:  Enzyme

Novelty:  0.02125361

Score:  0.939

Data Source:  STRINGDB

RHOJ

Tbio

Family:  Enzyme

Novelty:  0.01217051

Score:  0.933

Data Source:  STRINGDB

RAC2

Tbio

Family:  Enzyme

Novelty:  0.00116234

Score:  0.933

Data Source:  STRINGDB

RHOU

Tbio

Family:  Enzyme

Novelty:  0.01456329

Score:  0.93

Data Source:  STRINGDB

Publication Statistics

PubMed Score  29.83

PubMed score by year

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PubTator Score  42.3

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Cell junction
Cell membrane
Cell projection
Complete proteome
Cytoplasm
Endoplasmic reticulum
Endosome
Golgi apparatus

GWAS Trait Find Similar Targets

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atrial fibrillation
brain aneurysm
electrocardiography
mean platelet volume

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cellular phenotype
nervous system phenotype