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Tbio
IFITM5
Interferon-induced transmembrane protein 5

Protein Summary
Description
Required for normal bone mineralization. This gene encodes a membrane protein thought to play a role in bone mineralization. This gene is located on chromosome 11 in a cluster of related genes which are induced by interferon, however, this gene has not been shown to be interferon inducible. A similar gene, located in a gene cluster on mouse chromosome 7, is a member of the interferon-inducible fragilis gene family. The mouse gene encodes a transmembrane protein described as participating in germ cell competence. A mutation in the 5' UTR of this gene has been associated with osteogenesis imperfecta type V (PMID: 22863190, 22863195). [provided by RefSeq, Aug 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382614
  • ENSP00000372059
  • ENSG00000206013

Symbol
  • OI5
  • BRIL
  • DSPA1
  • Hrmp1
  • fragilis4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.58
cell line
0.49
PubMedID
0.49
transcription factor binding site profile
0.41
cell type or tissue
0.39


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.89   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.89   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (45)
1 – 10 of 45
COL10A1
Tbio
Novelty:  0.00521991
Score:  0.915
Data Source:  STRINGDB
SERPINF1
Tbio
Novelty:  0.00555849
Score:  0.788
Data Source:  STRINGDB
TMEM38B
Tbio
Family:  IC
Novelty:  0.0691148
Score:  0.78
Data Source:  STRINGDB
FKBP11
Tbio
Family:  Enzyme
Novelty:  0.10460718
Score:  0.756
Data Source:  STRINGDB
PGGHG
Tbio
Family:  Enzyme
Novelty:  0.40196205
Score:  0.736
Data Source:  STRINGDB
CRTAP
Tbio
Novelty:  0.02380647
Score:  0.714
Data Source:  STRINGDB
SYNDIG1L
Tdark
Novelty:  0.13042909
Score:  0.714
Data Source:  STRINGDB
P3H1
Tbio
Family:  Enzyme
Novelty:  0.02067711
Score:  0.699
Data Source:  STRINGDB
FKBP10
Tbio
Family:  Enzyme
Novelty:  0.01512539
Score:  0.692
Data Source:  STRINGDB
PLOD2
Tbio
Family:  Enzyme
Novelty:  0.00403916
Score:  0.607
Data Source:  STRINGDB
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
GWAS Traits (48)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
5
5
6
99.1
alkaline phosphatase measurement
3
3
3
17.9
96.7
eosinophil count
3
3
4
96.7
eosinophil percentage of leukocytes
2
4
4
96.5
monocyte percentage of leukocytes
2
3
4
96.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
6
99.1
alkaline phosphatase measurement
3
17.9
96.7
eosinophil count
4
96.7
eosinophil percentage of leukocytes
4
96.5
monocyte percentage of leukocytes
4
96.2
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interferon induced transmembrane protein 5
VGNC:1064
450915
Macaque
interferon induced transmembrane protein 5
697314
Mouse
MGI:1934923
73835
Rat
RGD:1307900
293617
Horse
interferon induced transmembrane protein 5
VGNC:18948
100050873
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interferon induced transmembrane protein 5
Macaque
interferon induced transmembrane protein 5
Mouse
Rat
Horse
interferon induced transmembrane protein 5
Publication Statistics
PubMed Score 74.89
PubMed score by year
PubTator Score 44.78
PubTator score by year