You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
COL6A6
Collagen alpha-6(VI) chain

Protein Summary
Description
Collagen VI acts as a cell-binding protein. This gene encodes a large protein that contains multiple von Willebrand factor domains and forms a component of the basal lamina of epithelial cells. This protein may regulate epithelial cell-fibronectin interactions. Variation in this gene may be implicated in skin diseases. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358511
  • ENSP00000351310
  • ENSG00000206384
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.88
cell line
0.56
pathway
0.53
cellular component
0.49
microRNA
0.47


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.68   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 52   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.68   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 52   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
collagen type VI alpha 6 chain
VGNC:53364
742913
Mouse
MGI:2444259
245026
Rat
RGD:1309172
315979
Dog
collagen type VI alpha 6 chain
VGNC:49850
610649
Horse
collagen type VI alpha 6 chain
VGNC:52365
100064285
Species
Name
OMA
EggNOG
Inparanoid
Chimp
collagen type VI alpha 6 chain
Mouse
Rat
Dog
collagen type VI alpha 6 chain
Horse
collagen type VI alpha 6 chain
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-A6NMZ7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (157)
Assembly of collagen fibrils and other multimeric structures (R-HSA-2022090)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Axon guidance
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen chain trimerization
Reactome
Collagen formation
Name
Explore in Pharos
Explore in Source
Assembly of collagen fibrils and other multimeric structures
Axon guidance
Collagen biosynthesis and modifying enzymes
Collagen chain trimerization
Collagen formation
Protein-Protein Interactions (102)
1 – 10 of 102
COL6A1
Tbio
Novelty: 0.00644855
Score: 0.96
Data Source: STRINGDB
COL6A2
Tbio
Novelty: 0.01275082
Score: 0.938
Data Source: STRINGDB
COL5A3
Tbio
Novelty: 0.06365591
Score: 0.93
Data Source: STRINGDB
COL4A4
Tbio
Novelty: 0.00833684
Score: 0.929
Data Source: STRINGDB
P4HA3
Tbio
Family: Enzyme
Novelty: 0.03832564
Score: 0.926
Data Source: STRINGDB
COL7A1
Tbio
Novelty: 0.00232977
Score: 0.925
Data Source: STRINGDB
COL14A1
Tbio
Novelty: 0.01760399
Score: 0.922
Data Source: STRINGDB
COL12A1
Tbio
Novelty: 0.0239421
Score: 0.921
Data Source: STRINGDB
COL8A1
Tbio
Novelty: 0.02203574
Score: 0.919
Data Source: STRINGDB
COL5A1
Tbio
Novelty: 0.00506815
Score: 0.918
Data Source: STRINGDB
Publication Statistics
PubMed Score  9.68

PubMed score by year
PubTator Score  4.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer