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Tdark
FAM170B
Protein FAM170B

Protein Summary
Description
Plays a role in fertilization through the acrosome reaction.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311787
  • ENSP00000308292
  • ENSG00000172538

Symbol
  • C10orf73
  • C10orf73
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.84
cell type or tissue
0.68
PubMedID
0.62
tissue sample
0.56
tissue
0.5


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.22   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 32   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.22   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 32   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
3
3
95.5
platelet crit
2
2
2
92.7
platelet count
2
2
2
91.2
leukocyte count
2
2
2
84.1
mean corpuscular volume
1
1
1
79.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
95.5
platelet crit
2
92.7
platelet count
2
91.2
leukocyte count
2
84.1
mean corpuscular volume
1
79.3
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2145650
105511
Rat
RGD:2318714
100362169
Horse
family with sequence similarity 170 member B
VGNC:17823
100629985
Cow
family with sequence similarity 170 member B
VGNC:28755
615859
Pig
family with sequence similarity 170 member B
100156206
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
family with sequence similarity 170 member B
Cow
family with sequence similarity 170 member B
Pig
family with sequence similarity 170 member B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-A6NMN3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (4)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (7)
1 – 7 of 7
GOPC
Tbio
Novelty:  0.01110168
Score:  0.691
Data Source:  STRINGDB
LRRC18
Tdark
Novelty:  1.02586195
Score:  0.664
Data Source:  STRINGDB
OGDHL
Tbio
Family:  Enzyme
Novelty:  0.05079572
Score:  0.563
Data Source:  STRINGDB
WDFY4
Tbio
Novelty:  0.15894833
Score:  0.56
Data Source:  STRINGDB
DRGX
Tbio
Family:  TF
Novelty:  0.0397402
Score:  0.554
Data Source:  STRINGDB
ARHGAP22
Tbio
Family:  Enzyme
Novelty:  0.13037853
Score:  0.52
Data Source:  STRINGDB
CSB-PGBD3
Tbio
Novelty:  0.01304541
Score:  0.425
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1.22

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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