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Tdark
TMEM88B
Transmembrane protein 88B

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378821
  • ENSP00000455099
  • ENSG00000205116
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.44
gene perturbation
0.44
tissue
0.42
cell type or tissue
0.4
PubMedID
0.38


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.53   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 4   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.53   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 4   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
1
2
2
52.7
heel bone mineral density
1
1
1
6.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
2
52.7
heel bone mineral density
1
6.7
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2444329
320587
Rat
RGD:1588243
680723
Dog
transmembrane protein 88B
VGNC:47612
100684204
Cow
transmembrane protein 88B
VGNC:36121
767837
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
transmembrane protein 88B
Cow
transmembrane protein 88B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-A6NKF7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (45)
1 – 10 of 45
TMEM179
Tdark
Novelty:  2.21288966
Score:  0.661
Data Source:  STRINGDB
FAM171B
Tdark
Novelty:  0.38456365
Score:  0.631
Data Source:  STRINGDB
FAM19A1
Tbio
Novelty:  0.27533335
Score:  0.63
Data Source:  STRINGDB
TMEM178A
Tdark
Novelty:  0.78925677
Score:  0.626
Data Source:  STRINGDB
TMEM145
Tdark
Novelty:  2.30428448
Score:  0.624
Data Source:  STRINGDB
TMEM130
Tdark
Novelty:  1.39618601
Score:  0.621
Data Source:  STRINGDB
FAM189A1
Tdark
Novelty:  0.94298311
Score:  0.617
Data Source:  STRINGDB
FAM131B
Tdark
Novelty:  0.3424123
Score:  0.611
Data Source:  STRINGDB
TMEM240
Tdark
Novelty:  0.05653095
Score:  0.609
Data Source:  STRINGDB
AMER3
Tdark
Novelty:  0.42348252
Score:  0.606
Data Source:  STRINGDB
Publication Statistics
PubMed Score  0.53

PubMed score by year
PubTator Score  0.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer