Tdark ASB14 Ankyrin repeat and SOCS box protein 14

Protein Summary

Description

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2008]

Uniprot Accession IDs

• A6NK59
• C9JX97
• Q8WXK2
• Q92816
• ASB-14

Gene Name

• ASB14

Ensembl ID

• ENST00000389601
• ENSP00000374252
• ENSG00000239388
• ENST00000487349
• ENSP00000419199

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.9
tissue sample	0.63
microRNA	0.51
cell type or tissue	0.48
cellular component	0.43

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.47   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 18   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.47   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 18   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0