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Tdark
ASB14
Ankyrin repeat and SOCS box protein 14

Protein Summary
Description
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389601
  • ENSP00000374252
  • ENSG00000239388
  • ENST00000487349
  • ENSP00000419199
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.9
tissue sample
0.63
microRNA
0.51
cell type or tissue
0.48
cellular component
0.43


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.45   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 18   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.45   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 18   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (312)
1 – 10 of 312
POTEF
Tbio
Novelty:  0.00191599
p_int:  0.981578692
p_ni:  0.018421307
p_wrong:  1e-9
Score:  0.308
Data Source:  BioPlex,STRINGDB
CISH
Tbio
Novelty:  0.00145893
Score:  0.95
Data Source:  STRINGDB
ASB4
Tbio
Novelty:  0.09903118
Score:  0.939
Data Source:  STRINGDB
ASB6
Tdark
Novelty:  0.32074223
Score:  0.938
Data Source:  STRINGDB
ASB16
Tdark
Novelty:  0.7376552
Score:  0.937
Data Source:  STRINGDB
ASB18
Tdark
Novelty:  1.29585637
Score:  0.931
Data Source:  STRINGDB
ASB10
Tbio
Novelty:  0.08667666
Score:  0.931
Data Source:  STRINGDB
FBXO31
Tbio
Novelty:  0.23426419
Score:  0.93
Data Source:  STRINGDB
ASB11
Tdark
Novelty:  0.84862254
Score:  0.93
Data Source:  STRINGDB
KLHL41
Tbio
Novelty:  0.03973182
Score:  0.928
Data Source:  STRINGDB
Pathways (8)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
1
1
5.5
1
1
0
5.7
3.2
family history of Alzheimer’s disease
1
1
0
5.7
3.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
5.5
0
5.7
3.2
family history of Alzheimer’s disease
0
5.7
3.2
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat and SOCS box containing 14
VGNC:11325
470829
Mouse
MGI:2655107
142687
Rat
RGD:1596812
680076
Dog
ankyrin repeat and SOCS box containing 14
VGNC:38158
607136
Horse
ankyrin repeat and SOCS box containing 14
VGNC:15566
100058612
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat and SOCS box containing 14
Mouse
Rat
Dog
ankyrin repeat and SOCS box containing 14
Horse
ankyrin repeat and SOCS box containing 14
Publication Statistics
PubMed Score 0.45
PubMed score by year
PubTator Score 8.50
PubTator score by year