You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
LIPT2
Putative lipoyltransferase 2, mitochondrial

Protein Summary
Description
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes, which catalyze essential redox reactions (PubMed:28757203). Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity). This gene encodes a mitochondrial protein that catalyzes the transfer of octanoic acid to lipoate-dependent enzymes such as octanoyl-ACP. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310109
  • ENSP00000309463
  • ENSG00000175536
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
transcription factor binding site profile
0.59
tissue sample
0.55
cell line
0.48
cellular component
0.48


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.61   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.61   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
73
1
1
0
1.1
73
hematocrit
1
1
1
57.3
hemoglobin measurement
1
1
1
57.3
grip strength measurement
1
1
1
36.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
73
0
1.1
73
hematocrit
1
57.3
hemoglobin measurement
1
57.3
grip strength measurement
1
36.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lipoyl(octanoyl) transferase 2
VGNC:48934
451421
Macaque
lipoyl(octanoyl) transferase 2
718425
Mouse
MGI:1914414
67164
Rat
RGD:1305211
365314
Dog
lipoyl(octanoyl) transferase 2
VGNC:52265
485196
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lipoyl(octanoyl) transferase 2
Macaque
lipoyl(octanoyl) transferase 2
Mouse
Rat
Dog
lipoyl(octanoyl) transferase 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-A6NK58-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Glyoxylate metabolism and glycine degradation (R-HSA-389661)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glyoxylate metabolism and glycine degradation
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Glyoxylate metabolism and glycine degradation
Metabolism
Metabolism of amino acids and derivatives
Protein-Protein Interactions (45)
1 – 10 of 45
GCSH
Tbio
Novelty:  0.02101972
Score:  0.993
Data Source:  STRINGDB
LIAS
Tbio
Family:  Enzyme
Novelty:  0.01269062
Score:  0.992
Data Source:  STRINGDB
LIPT1
Tdark
Family:  Enzyme
Novelty:  0.0546324
Score:  0.992
Data Source:  STRINGDB
NDUFAB1
Tclin
Novelty:  0.00190242
Score:  0.976
Data Source:  STRINGDB
DLAT
Tbio
Family:  Enzyme
Novelty:  0.00311191
Score:  0.88
Data Source:  STRINGDB
OXSM
Tbio
Family:  Enzyme
Novelty:  0.00615894
Score:  0.833
Data Source:  STRINGDB
FASN
Tchem
Family:  Enzyme
Novelty:  0.00142172
Score:  0.8
Data Source:  STRINGDB
METTL17
Tbio
Family:  Enzyme
Novelty:  0.55944382
Score:  0.785
Data Source:  STRINGDB
NFU1
Tbio
Novelty:  0.01465025
Score:  0.774
Data Source:  STRINGDB
OGDH
Tbio
Family:  Enzyme
Novelty:  0.00674601
Score:  0.715
Data Source:  STRINGDB
Publication Statistics
PubMed Score  3.61

PubMed score by year
PubTator Score  4.89

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer