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Tbio
ACOD1
Cis-aconitate decarboxylase

Protein Summary
Description
Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377462
  • ENSP00000366682
  • ENSG00000102794

Symbol
  • IRG1
  • CAD
  • IRG1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.48   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 70   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.48   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (38)
1 – 10 of 38
IL1B
Tclin
Novelty:  0.0000308
Score:  0.767
Data Source:  STRINGDB
CCL4
Tbio
Novelty:  0.00069278
Score:  0.669
Data Source:  STRINGDB
CS
Tbio
Family:  Enzyme
Novelty:  0.00154214
Score:  0.654
Data Source:  STRINGDB
CPA6
Tbio
Family:  Enzyme
Novelty:  0.05034597
Score:  0.652
Data Source:  STRINGDB
ZC3H12A
Tbio
Family:  Enzyme
Novelty:  0.00651373
Score:  0.635
Data Source:  STRINGDB
IRF1
Tbio
Family:  TF
Novelty:  0.00099983
Score:  0.612
Data Source:  STRINGDB
GIMAP7
Tbio
Family:  Enzyme
Novelty:  0.15758026
Score:  0.605
Data Source:  STRINGDB
CLEC4E
Tchem
Novelty:  0.00793367
Score:  0.586
Data Source:  STRINGDB
CXCL10
Tbio
Novelty:  0.00040194
Score:  0.565
Data Source:  STRINGDB
SPATA18
Tbio
Novelty:  0.07874671
Score:  0.564
Data Source:  STRINGDB
Gene Ontology Terms (23)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
3
3
2
1.1
93.8
circadian rhythm
1
1
0
1.2
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
1.1
93.8
circadian rhythm
0
1.2
15.8
Find similar targets by:
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aconitate decarboxylase 1
VGNC:13062
452753
Mouse
MGI:103206
16365
Rat
RGD:1563454
306127
Dog
aconitate decarboxylase 1
VGNC:37515
485496
Horse
aconitate decarboxylase 1
VGNC:14987
100052594
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aconitate decarboxylase 1
Mouse
Rat
Dog
aconitate decarboxylase 1
Horse
aconitate decarboxylase 1
Publication Statistics
PubMed Score 96.48
PubMed score by year
PubTator Score 233.77
PubTator score by year