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Tbio
UNC119B
Protein unc-119 homolog B

Protein Summary
Description
Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated NPHP3 and plays a key role in localization of NPHP3 to the primary cilium membrane. Does not bind all myristoylated proteins. Probably plays a role in trafficking proteins in photoreceptor cells.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344651
  • ENSP00000344942
  • ENSG00000175970

Symbol
  • POC7B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.71
disease perturbation
0.68
kinase perturbation
0.66
virus perturbation
0.64
cell type or tissue
0.56


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.56   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.56   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (30)
RNF34
Tbio
Family:  Enzyme
Novelty:  0.04365307
p_int:  0.999929847
p_ni:  0.000070153
Score:  0.827
Data Source:  BioPlex,STRINGDB
UNC119
Tchem
Novelty:  0.00396292
p_int:  0.997765162
p_ni:  0.002234832
p_wrong:  6e-9
Score:  0.831
Data Source:  BioPlex,STRINGDB
NPHP3
Tbio
Novelty:  0.02857926
p_int:  0.995288702
p_ni:  0.004711296
p_wrong:  2e-9
Score:  0.993
Data Source:  BioPlex,Reactome,STRINGDB
PALD1
Tbio
Novelty:  0.0248863
p_int:  0.995199211
p_ni:  0.004800789
Data Source:  BioPlex
AVPI1
Tdark
Novelty:  0.28472403
p_int:  0.961027916
p_ni:  0.038972084
Data Source:  BioPlex
PSKH2
Tdark
Family:  Kinase
Novelty:  1.70921715
p_int:  0.837807911
p_ni:  0.162192089
Score:  0.87
Data Source:  BioPlex,STRINGDB
ARL3
Tbio
Family:  Enzyme
Novelty:  0.01954965
Score:  0.992
Data Source:  Reactome,STRINGDB
CYS1
Tdark
Novelty:  0.0036908
Score:  0.918
Data Source:  Reactome,STRINGDB
RP2
Tbio
Novelty:  0.12345247
Score:  0.9
Data Source:  Reactome,STRINGDB
ARL13B
Tbio
Family:  Enzyme
Novelty:  0.01481674
Score:  0.785
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Cargo trafficking to the periciliary membrane (R-HSA-5620920)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo trafficking to the periciliary membrane
Reactome
Cilium Assembly
Reactome
Organelle biogenesis and maintenance
Reactome
Trafficking of myristoylated proteins to the cilium
Name
Explore in Pharos
Explore in Source
Cargo trafficking to the periciliary membrane
Cilium Assembly
Organelle biogenesis and maintenance
Trafficking of myristoylated proteins to the cilium
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (33)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
4
5
5
99.1
serum metabolite measurement
3
4
5
98.2
C-reactive protein measurement
2
12
12
98.2
serum gamma-glutamyl transferase measurement
1
10
10
97.2
red blood cell distribution width
4
3
4
95.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
5
99.1
serum metabolite measurement
5
98.2
C-reactive protein measurement
12
98.2
serum gamma-glutamyl transferase measurement
10
97.2
red blood cell distribution width
4
95.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
unc-119 lipid binding chaperone B
VGNC:5643
742885
Mouse
MGI:2147162
106840
Dog
unc-119 lipid binding chaperone B
VGNC:48134
611530
Horse
unc-119 lipid binding chaperone B
VGNC:24790
100052886
Cow
unc-119 lipid binding chaperone B
VGNC:36663
617896
Species
Name
OMA
EggNOG
Inparanoid
Chimp
unc-119 lipid binding chaperone B
Mouse
Dog
unc-119 lipid binding chaperone B
Horse
unc-119 lipid binding chaperone B
Cow
unc-119 lipid binding chaperone B
Publication Statistics
PubMed Score 3.56
PubMed score by year
PubTator Score 1.35
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title