Tbio UNC119B Protein unc-119 homolog B

Protein Summary

Description

Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated NPHP3 and plays a key role in localization of NPHP3 to the primary cilium membrane. Does not bind all myristoylated proteins. Probably plays a role in trafficking proteins in photoreceptor cells.

Uniprot Accession IDs

• A6NIH7

Gene Name

• UNC119B

Ensembl ID

• ENST00000344651
• ENSP00000344942
• ENSG00000175970

Symbol

• POC7B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.71
disease perturbation	0.68
kinase perturbation	0.66
virus perturbation	0.64
cell type or tissue	0.56

Protein Classes

PANTHER Classes

Protein / Receptor / Protein Unc-119 Homolog B

DTO Classes

Protein / Receptor / Protein Unc-119 Homolog B

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.85   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 57   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.85   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0