LILRA5
Leukocyte immunoglobulin-like receptor subfamily A member 5
Protein Summary
May play a role in triggering innate immune responses. Does not seem to play a role for any class I MHC antigen recognition. The protein encoded by this gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family. LIR family members are known to have activating and inibitory functions in leukocytes. Crosslink of this receptor protein on the surface of monocytes has been shown to induce calcium flux and secretion of several proinflammatory cytokines, which suggests the roles of this protein in triggering innate immune responses. This gene is one of the leukocyte receptor genes that form a gene cluster on the chromosomal region 19q13.4. Four alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
- ENST00000432233
- ENSP00000404236
- ENSG00000187116
- ENST00000486742
- ENSP00000484372
- ENST00000611164
- ENSP00000482658
- ENSG00000278355
- ENST00000612266
- ENSP00000480436
- ENSG00000274914
- ENST00000612621
- ENSP00000484785
- ENST00000613559
- ENSP00000484775
- ENST00000614299
- ENSP00000483992
- ENST00000615820
- ENSP00000480204
- ENSG00000274113
- ENST00000616133
- ENSP00000484062
- ENSG00000275404
- ENST00000618711
- ENSP00000478354
- ENST00000619516
- ENSP00000480382
- ENST00000620091
- ENSP00000480458
- ENST00000620692
- ENSP00000483958
- ENST00000620898
- ENSP00000484869
- ENST00000621042
- ENSP00000482882
- ENST00000621482
- ENSP00000477785
- ILT11
- LILRB7
- LIR9
- CD85
- LIR9
- CD85F
- ILT11
- LIR-9
- ILT-11
- LILRB7
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
tissue sample | 0.62 | ||
tissue | 0.59 | ||
cell line | 0.57 | ||
kinase perturbation | 0.54 | ||
transcription factor | 0.47 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16.62 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 140 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16.62 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 140 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0