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Tbio
ARHGAP42
Rho GTPase-activating protein 42

Protein Summary
Description
May influence blood pressure by functioning as a GTPase-activating protein for RHOA in vascular smooth muscle. This gene encodes a Rho GTPase-activating protein (RhoGAP), and member of the GRAF or BAR-PH family of proteins. Expression of this gene is enriched in vascular smooth muscle cells and the encoded protein inhibits RhoA activity to regulate vascular tone and control blood pressure. A mutation in the first intron of this gene modulates its expression and is associated with reduced blood pressure in human patients with borderline hypertension. [provided by RefSeq, Jul 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298815
  • ENSP00000298815
  • ENSG00000165895

Symbol
  • GRAF3
  • AD031
  • GRAF3
  • TMEM133
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.86
protein domain
0.73
histone modification site profile
0.7
phenotype
0.67
tissue sample
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.77   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 42   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.77   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
5
5
9
87
3
5
6
87
4
3
4
75.2
mean arterial pressure
2
2
2
71
reticulocyte count
5
2
5
68
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
9
87
6
87
4
75.2
mean arterial pressure
2
71
reticulocyte count
5
68
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rho GTPase activating protein 42
VGNC:3209
451501
Mouse
MGI:1918794
71544
Rat
RGD:1564081
500943
Dog
Rho GTPase activating protein 42
VGNC:38064
476762
Cow
Rho GTPase activating protein 42
VGNC:26096
508009
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rho GTPase activating protein 42
Mouse
Rat
Dog
Rho GTPase activating protein 42
Cow
Rho GTPase activating protein 42
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-A6NI28-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Rho GTPase cycle (R-HSA-194840)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
Rho GTPase cycle
Signal Transduction
Signaling by Rho GTPases
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (46)
1 – 10 of 46
ARHGAP26
Tbio
Family: Enzyme
Novelty: 0.02409941
p_int: 0.999999978
p_ni: 1e-8
p_wrong: 1.2e-8
Score: 0.314
Data Source: BioPlex,STRINGDB
DEF6
Tbio
Novelty: 0.0378487
p_int: 0.999999919
p_ni: 5.3e-8
p_wrong: 2.8e-8
Score: 0.288
Data Source: BioPlex,STRINGDB
DENND2C
Tbio
Novelty: 1.37746285
p_int: 0.999989861
p_ni: 0.000010125
p_wrong: 1.4e-8
Score: 0.503
Data Source: BioPlex,STRINGDB
RHOA
Tbio
Family: Enzyme
Novelty: 0.00022204
Score: 0.916
Data Source: STRINGDB
CDC42
Tchem
Family: Enzyme
Novelty: 0.00032619
Score: 0.907
Data Source: STRINGDB
RHOD
Tbio
Family: Enzyme
Novelty: 0.0029764
Score: 0.903
Data Source: STRINGDB
RHOC
Tbio
Family: Enzyme
Novelty: 0.00262213
Score: 0.902
Data Source: STRINGDB
RAC1
Tbio
Family: Enzyme
Novelty: 0.00365325
Score: 0.901
Data Source: STRINGDB
RHOB
Tbio
Family: Enzyme
Novelty: 0.0019205
Score: 0.901
Data Source: STRINGDB
RHOT2
Tbio
Family: Enzyme
Novelty: 0.01712732
Score: 0.901
Data Source: STRINGDB
Publication Statistics
PubMed Score  7.77

PubMed score by year
PubTator Score  4.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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