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Tbio
CASTOR2
Cytosolic arginine sensor for mTORC1 subunit 2

Protein Summary
Description
Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2-containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000616305
  • ENSP00000484732
  • ENSG00000274070

Symbol
  • GATSL1
  • GATSL2
  • GATSL1
  • GATSL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.99   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 26   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.99   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 26   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
13.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
13.6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-A6NHX0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (39)
1 – 10 of 39
CASTOR1
Tbio
Novelty: 0.10145237
p_int: 0.999999991
p_ni: 3e-9
p_wrong: 6e-9
Score: 0.697
Data Source: BioPlex,Reactome,STRINGDB
MIOS
Tdark
Novelty: 0.04252507
Score: 0.735
Data Source: STRINGDB
SLC38A9
Tbio
Family: Transporter
Novelty: 0.0879703
Score: 0.726
Data Source: STRINGDB
WDR24
Tdark
Novelty: 0.48411996
Score: 0.705
Data Source: STRINGDB
WDR59
Tdark
Novelty: 0.22243351
Score: 0.701
Data Source: STRINGDB
FAM25A
Tdark
Novelty: 1.81526954
Score: 0.66
Data Source: STRINGDB
ZC2HC1A
Tdark
Novelty: 0.75491818
Score: 0.574
Data Source: STRINGDB
RGPD5
Tbio
Novelty: 0.13776125
Score: 0.551
Data Source: STRINGDB
SEH1L
Tbio
Novelty: 0.03666501
Score: 0.548
Data Source: STRINGDB
LAMTOR4
Tdark
Novelty: 0.24218646
Score: 0.518
Data Source: STRINGDB
Publication Statistics
PubMed Score  2.99

PubMed score by year
PubTator Score  0.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer