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Tbio
HMX3
Homeobox protein HMX3

Protein Summary
Description
Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence. Controls semicircular canal formation in the inner ear. Also required for hypothalamic/pituitary axis of the CNS (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357878
  • ENSP00000350549
  • ENSG00000188620

Symbol
  • NKX-5.1
  • NKX5-1
  • NKX5.1
  • Nkx5-1
  • NKX-5.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.86
tissue
0.7
phenotype
0.62
PubMedID
0.59
protein domain
0.58


Related Tools
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.78   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.78   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
H6 family homeobox 3
707798
Mouse
MGI:107160
15373
Rat
RGD:1559927
293537
Dog
H6 family homeobox 3
VGNC:49908
611245
Horse
H6 family homeobox 3
VGNC:18817
100057903
Species
Name
OMA
EggNOG
Inparanoid
Macaque
H6 family homeobox 3
Mouse
Rat
Dog
H6 family homeobox 3
Horse
H6 family homeobox 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-A6NHT5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (38)
1 – 10 of 38
LHX6
Tbio
Family: TF
Novelty: 0.01603143
Score: 0.723
Data Source: STRINGDB
HINFP
Tbio
Family: TF
Novelty: 0.09086304
Score: 0.711
Data Source: STRINGDB
PPP1R21
Tdark
Family: Enzyme
Novelty: 0.33099657
Score: 0.711
Data Source: STRINGDB
LHX8
Tbio
Family: TF
Novelty: 0.01815234
Score: 0.604
Data Source: STRINGDB
TACC2
Tbio
Novelty: 0.05063528
Score: 0.56
Data Source: STRINGDB
NRAP
Tbio
Novelty: 0.15548332
Score: 0.56
Data Source: STRINGDB
DTNA
Tbio
Novelty: 0.01165754
Score: 0.556
Data Source: STRINGDB
ISY1
Tdark
Novelty: 1.68602768
Score: 0.556
Data Source: STRINGDB
DTNB
Tbio
Novelty: 0.0586565
Score: 0.556
Data Source: STRINGDB
WNT7A
Tbio
Novelty: 0.00421662
Score: 0.547
Data Source: STRINGDB
Publication Statistics
PubMed Score  13.78

PubMed score by year
PubTator Score  5.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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