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Tdark
TUBAL3
Tubulin alpha chain-like 3

Protein Summary
Description
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380419
  • ENSP00000369784
  • ENSG00000178462
  • ENST00000479328
  • ENSP00000418799
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
protein domain
0.92
protein complex
0.75
cell type or tissue
0.67
interacting protein
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.07   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 169   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.07   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
1
1
38.8
triglyceride measurement
1
1
1
5.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
38.8
triglyceride measurement
1
5.3
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
tubulin alpha like 3
722506
Mouse
MGI:3588215
238463
Horse
tubulin alpha like 3
VGNC:24656
100146855
Cow
tubulin alpha like 3
VGNC:36505
538631
Pig
tubulin alpha like 3
100623355
Species
Name
OMA
EggNOG
Inparanoid
Macaque
tubulin alpha like 3
Mouse
Horse
tubulin alpha like 3
Cow
tubulin alpha like 3
Pig
tubulin alpha like 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-A6NHL2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (13)
Chaperonin-mediated protein folding (R-HSA-390466)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chaperonin-mediated protein folding
Reactome
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Reactome
Formation of tubulin folding intermediates by CCT/TriC
Reactome
Metabolism of proteins
Reactome
Post-chaperonin tubulin folding pathway
Name
Explore in Pharos
Explore in Source
Chaperonin-mediated protein folding
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Formation of tubulin folding intermediates by CCT/TriC
Metabolism of proteins
Post-chaperonin tubulin folding pathway
Gene Ontology Terms (8)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (86)
1 – 10 of 86
TCP11L2
Tdark
Novelty:  1.78903335
p_int:  0.999496727
p_ni:  0.000210579
p_wrong:  0.000292694
Score:  0.165
Data Source:  BioPlex,STRINGDB
TXNDC9
Tbio
Novelty:  0.00309772
p_int:  0.998402755
p_ni:  0.001597246
Score:  0.849
Data Source:  BioPlex,STRINGDB
TCP1
Tbio
Novelty:  0.00395241
p_int:  0.992432128
p_ni:  0.007567872
Score:  0.918
Data Source:  BioPlex,STRINGDB
CCT6B
Tdark
Novelty:  0.28933315
p_int:  0.991567687
p_ni:  0.008432313
Score:  0.923
Data Source:  BioPlex,STRINGDB
NEDD1
Tbio
Novelty:  0.03077131
p_int:  0.982916649
p_ni:  0.012308282
p_wrong:  0.004775069
Data Source:  BioPlex
CCT4
Tbio
Novelty:  0.01176123
p_int:  0.975014083
p_ni:  0.024985918
Score:  0.918
Data Source:  BioPlex,STRINGDB
CCT3
Tbio
Novelty:  0.01642521
p_int:  0.966556853
p_ni:  0.033443147
Score:  0.963
Data Source:  BioPlex,STRINGDB
CAPS
Tbio
Novelty:  0.04549022
p_int:  0.964387761
p_ni:  0.035612239
Data Source:  BioPlex
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.941507412
p_ni:  0.058492588
Score:  0.968
Data Source:  BioPlex,STRINGDB
CCT7
Tbio
Novelty:  0.02247038
p_int:  0.903417162
p_ni:  0.096582839
Score:  0.957
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  1.07

PubMed score by year
PubTator Score  0.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer