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Tbio
CAPN8
Calpain-8

Protein Summary
Description
Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366872
  • ENSP00000355837
  • ENSG00000203697

Symbol
  • NCL2
  • nCL-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
virus perturbation
0.79
tissue sample
0.68
gene perturbation
0.56
cellular component
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.06   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 66   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.06   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alpha-carotene measurement
1
1
1
1.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alpha-carotene measurement
1
1.3
Pathways (2)
Degradation of the extracellular matrix (R-HSA-1474228)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Degradation of the extracellular matrix
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Degradation of the extracellular matrix
Extracellular matrix organization
Protein-Protein Interactions (75)
1 – 10 of 75
CAST
Tbio
Novelty: 0.00099404
p_int: 0.999999959
p_ni: 4.1e-8
Score: 0.994
Data Source: BioPlex,STRINGDB
CAPN1
Tchem
Novelty: 0.00252811
p_int: 0.99956343
p_ni: 0.00043657
Score: 0.83
Data Source: BioPlex,STRINGDB
FNTB
Tchem
Family: Enzyme
Novelty: 0.07434994
p_int: 0.939169511
p_ni: 0.060482116
p_wrong: 0.000348373
Score: 0.757
Data Source: BioPlex,STRINGDB
RPS3
Tbio
Novelty: 0.003106
p_int: 0.914380623
p_ni: 0.085619377
Score: 0.189
Data Source: BioPlex,STRINGDB
CAPNS1
Tbio
Novelty: 0.00954566
Score: 0.915
Data Source: STRINGDB
CAPNS2
Tbio
Novelty: 0.45658116
Score: 0.909
Data Source: STRINGDB
CASP3
Tchem
Family: Enzyme
Novelty: 0.00003555
Score: 0.67
Data Source: STRINGDB
ANKDD1A
Tdark
Novelty: 1.522813
Score: 0.668
Data Source: STRINGDB
CTSB
Tchem
Family: Enzyme
Novelty: 0.00026238
Score: 0.663
Data Source: STRINGDB
GABRE
Tclin
Family: IC
Novelty: 0.03814541
Score: 0.653
Data Source: STRINGDB
Publication Statistics
PubMed Score  28.06

PubMed score by year
PubTator Score  17.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer