You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
TVP23A
Golgi apparatus membrane protein TVP23 homolog A

Protein Summary
Description
This gene encodes a membrane protein associated with the Golgi apparatus, which plays a crucial role in intracellular vesicular transport. The encoded protein is likely associated with the late (trans) Golgi compartments, which are involved in the delivery of secretory and membrane proteins to the endosome, lysosome or the plasma membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299866
  • ENSP00000299866
  • ENSG00000166676
  • ENST00000456096
  • ENSP00000411972
  • ENST00000575135
  • ENSP00000460567
  • ENST00000612195
  • ENSP00000482891

Symbol
  • FAM18A
  • FAM18A
  • YDR084C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.52
tissue sample
0.52
microRNA
0.42
transcription factor
0.42
phenotype
0.41


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.08   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 4   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.08   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 4   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
1
1
66.3
monocyte percentage of leukocytes
1
1
1
61.4
waist-hip ratio
1
1
1
44.2
BMI-adjusted waist-hip ratio
1
1
1
42.3
1
1
0
1.1
38.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
66.3
monocyte percentage of leukocytes
1
61.4
waist-hip ratio
1
44.2
BMI-adjusted waist-hip ratio
1
42.3
0
1.1
38.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
trans-golgi network vesicle protein 23 homolog A
VGNC:9396
453913
Mouse
MGI:3665441
383103
Rat
RGD:1566405
360467
Dog
trans-golgi network vesicle protein 23 homolog A
VGNC:48000
490009
Horse
trans-golgi network vesicle protein 23 homolog A [Source:HGNC Symbol;Acc:HGNC:20398]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
trans-golgi network vesicle protein 23 homolog A
Mouse
Rat
Dog
trans-golgi network vesicle protein 23 homolog A
Horse
trans-golgi network vesicle protein 23 homolog A [Source:HGNC Symbol;Acc:HGNC:20398]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-A6NH52-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (8)
1 – 8 of 8
YIPF1
Tbio
Novelty:  0.00507381
p_int:  0.869591395
p_ni:  1.1e-8
p_wrong:  0.130408594
Score:  0.303
Data Source:  BioPlex,STRINGDB
YIPF6
Tdark
Novelty:  0.04316252
Score:  0.602
Data Source:  STRINGDB
FBXL13
Tdark
Novelty:  0.33362589
Score:  0.596
Data Source:  STRINGDB
LRRC17
Tdark
Novelty:  0.16875862
Score:  0.559
Data Source:  STRINGDB
SPDYE2
Tdark
Novelty:  1.21600883
Score:  0.45
Data Source:  STRINGDB
POLR2J3
Tdark
Family:  Enzyme
Novelty:  0.96582106
Score:  0.438
Data Source:  STRINGDB
ALKBH4
Tbio
Family:  Enzyme
Novelty:  0.34513259
Score:  0.424
Data Source:  STRINGDB
PRKRIP1
Tdark
Novelty:  0.24236931
Score:  0.42
Data Source:  STRINGDB
Publication Statistics
PubMed Score  0.08

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer