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Tdark
WIPF3
WAS/WASL-interacting protein family member 3

Protein Summary
Description
May be a regulator of cytoskeletal organization. May have a role in spermatogenesis (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000242140
  • ENSP00000242140
  • ENSG00000122574
  • ENST00000409290
  • ENSP00000386878

Symbol
  • CR16
  • CR16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.88
microRNA
0.6
tissue sample
0.6
disease
0.55
tissue
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.86   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 23   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.86   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 23   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (69)
NCK2
Tbio
Novelty:  0.02220251
p_int:  0.999999973
p_ni:  2.5e-8
p_wrong:  1e-9
Score:  0.621
Data Source:  BioPlex,STRINGDB
NCK1
Tbio
Novelty:  0.00352084
p_int:  0.999999839
p_ni:  1.31e-7
p_wrong:  3e-8
Score:  0.947
Data Source:  BioPlex,Reactome,STRINGDB
WASL
Tbio
Novelty:  0.0029314
p_int:  0.999999348
p_ni:  2e-9
p_wrong:  6.5e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
GRB2
Tchem
Novelty:  0.00091605
p_int:  0.998626528
p_ni:  0.000011637
p_wrong:  0.001361834
Score:  0.705
Data Source:  BioPlex,Reactome,STRINGDB
WAS
Tbio
Novelty:  0.00087362
Score:  0.991
Data Source:  Reactome,STRINGDB
ACTR2
Tchem
Novelty:  0.00731489
Score:  0.977
Data Source:  STRINGDB
ACTR3
Tchem
Novelty:  0.02112745
Score:  0.948
Data Source:  STRINGDB
ARPC5
Tbio
Novelty:  0.03434234
Score:  0.947
Data Source:  STRINGDB
WASF1
Tbio
Novelty:  0.00977488
Score:  0.945
Data Source:  STRINGDB
ACTB
Tbio
Novelty:  0.00006048
Score:  0.937
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Fcgamma receptor (FCGR) dependent phagocytosis (R-HSA-2029480)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases Activate WASPs and WAVEs
Name
Explore in Pharos
Explore in Source
Fcgamma receptor (FCGR) dependent phagocytosis
Immune System
Innate Immune System
RHO GTPase Effectors
RHO GTPases Activate WASPs and WAVEs
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.6
93
urinary albumin to creatinine ratio
3
2
3
80.5
heel bone mineral density
2
1
2
61
myeloid white cell count
1
1
1
32.3
albuminuria
1
1
1
16.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.6
93
urinary albumin to creatinine ratio
3
80.5
heel bone mineral density
2
61
myeloid white cell count
1
32.3
albuminuria
1
16.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WAS/WASL interacting protein family member 3
VGNC:14116
463322
Mouse
MGI:3044681
330319
Rat
RGD:708559
259242
Dog
WAS/WASL interacting protein family member 3
VGNC:54799
100684384
Horse
WAS/WASL interacting protein family member 3 [Source:HGNC Symbol;Acc:HGNC:22004]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WAS/WASL interacting protein family member 3
Mouse
Rat
Dog
WAS/WASL interacting protein family member 3
Horse
WAS/WASL interacting protein family member 3 [Source:HGNC Symbol;Acc:HGNC:22004]
Publication Statistics
PubMed Score 53.86
PubMed score by year
PubTator Score 14.22
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title