Tdark TMEM235 Transmembrane protein 235

Protein Summary

Uniprot Accession IDs

• A6NFC5
• C9JRE6

Gene Name

• TMEM235

Ensembl ID

• ENST00000374946
• ENSP00000364084
• ENSG00000204278
• ENST00000421688
• ENSP00000402790
• ENST00000550981
• ENSP00000447766
• ENST00000551068
• ENSP00000446514
• ENST00000586400
• ENSP00000466793

Symbol

• ARGM1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.77
cell type or tissue	0.63
cell line	0.53
tissue	0.42
biological term	0.33

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.44   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 4   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.44   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 4   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

tutorial

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (70)

Explore Interacting Targets

1 – 10 of 70

• See Interactions on String-DB

OPALIN

Tdark

Novelty:  0.08221612

Score:  0.771

Data Source:  STRINGDB

MAG

Tchem

Novelty:  0.00085621

Score:  0.702

Data Source:  STRINGDB

HAPLN2

Tbio

Novelty:  0.13206172

Score:  0.608

Data Source:  STRINGDB

CLDND1

Tbio

Novelty:  0.06681793

Score:  0.603

Data Source:  STRINGDB

KCNJ9

Tbio

Family:  IC

Novelty:  0.02279401

Score:  0.578

Data Source:  STRINGDB

NTSR2

Tchem

Family:  GPCR

Novelty:  0.00699381

Score:  0.561

Data Source:  STRINGDB

HTR5A

Tchem

Family:  GPCR

Novelty:  0.0160551

Score:  0.537

Data Source:  STRINGDB

CA10

Tbio

Family:  Enzyme

Novelty:  0.01053152

Score:  0.531

Data Source:  STRINGDB

TCEAL6

Tdark

Novelty:  0.88185411

Score:  0.528

Data Source:  STRINGDB

MT3

Tbio

Novelty:  0.00321947

Score:  0.526

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (3)

Components (3)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
apical plasma membrane	Inferred from Electronic Annotation (IEA)	Ensembl
endoplasmic reticulum	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell
integral component of membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (16)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 16

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
HbA1c measurement	EFO_0004541	2	7	8		98.4
red blood cell distribution width	EFO_0005192	3	4	6		97.2
reticulocyte count	EFO_0007986	7	5	12		94.2
mean corpuscular volume	EFO_0004526	1	2	2		93.3
reticulocyte measurement	EFO_0010700	3	3	5		91.5

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 16

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
HbA1c measurement	EFO_0004541	8		98.4
red blood cell distribution width	EFO_0005192	6		97.2
reticulocyte count	EFO_0007986	12		94.2
mean corpuscular volume	EFO_0004526	2		93.3
reticulocyte measurement	EFO_0010700	5		91.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Endoplasmic reticulum
Glycoprotein
Membrane
Reference proteome
Signal
Transmembrane
Transmembrane helix

GWAS Trait Find Similar Targets

No Header	No Header
C-reactive protein measurement
creatine kinase measurement
eosinophil count
eosinophil percentage of leukocytes
HbA1c measurement
hemolysis
leukocyte count
lymphocyte count
mean corpuscular volume
mean reticulocyte volume

IDG Resources

No IDG generated resources found

Orthologs (6)

1 – 5 of 6

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	transmembrane protein 235	MGI:3651706	546519
Rat	transmembrane protein 235	RGD:1591141	688285
Dog	transmembrane protein 235	VGNC:47545	491549
Horse	transmembrane protein 235 [Source:HGNC Symbol;Acc:HGNC:27563]
Cow	transmembrane protein 235	VGNC:36048	536606

Species	Name	OMA	EggNOG	Inparanoid
Mouse	transmembrane protein 235
Rat	transmembrane protein 235
Dog	transmembrane protein 235
Horse	transmembrane protein 235 [Source:HGNC Symbol;Acc:HGNC:27563]
Cow	transmembrane protein 235

Publication Statistics

PubMed Score 0.44

PubMed score by year

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Related Publications

Text Mined References (2)

GeneRif Annotations (1)

Items per page:

10

0 of 0

PMID	Year	Title