TRABD2B
Metalloprotease TIKI2
Protein Summary
Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation.
- ENST00000606738
- ENSP00000476820
- ENSG00000269113
- HKAT
- TIKI2
- TIKI2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cellular component | 0.76 | ||
microRNA | 0.71 | ||
tissue | 0.66 | ||
cell type or tissue | 0.63 | ||
tissue sample | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.45 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 6 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.45 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 6 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (10)
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (3)
Components (3)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
vitamin D measurement | 1 | 1 | 1 | 48.5 | |||||
heel bone mineral density | 3 | 2 | 3 | 47.5 | |||||
balding measurement | 1 | 1 | 1 | 35 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
vitamin D measurement | 1 | 48.5 | |||||
heel bone mineral density | 3 | 47.5 | |||||
balding measurement | 1 | 35 | |||||
Find similar targets by:
IDG Resources
Orthologs (3)
1 – 3 of 3
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:3650152 | 666048 | ||||||
Rat | RGD:1586386 | 689914 | ||||||
Horse | TraB domain containing 2B | VGNC:24452 | 100063464 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Horse | TraB domain containing 2B | |||||
Publication Statistics
PubMed Score 10.45
PubMed score by year
PubTator Score 3.50
PubTator score by year
Related Publications
Text Mined References (11)
GeneRif Annotations (4)
Items per page:
0 of 0
PMID | Year | Title |
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