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Tbio
TRABD2B
Metalloprotease TIKI2

Protein Summary
Description
Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000606738
  • ENSP00000476820
  • ENSG00000269113

Symbol
  • HKAT
  • TIKI2
  • TIKI2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.76
microRNA
0.71
tissue
0.66
cell type or tissue
0.63
tissue sample
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.15   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 6   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.15   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 6   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
1
2
65.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
65.2
Gene Ontology Terms (11)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (10)
1 – 10 of 10
SLC5A9
Tbio
Family: Transporter
Novelty: 0.10768341
Score: 0.762
Data Source: STRINGDB
TRABD
Tdark
Novelty: 0.47132923
Score: 0.738
Data Source: STRINGDB
AADAT
Tchem
Family: Enzyme
Novelty: 0.00678753
Score: 0.705
Data Source: STRINGDB
KYAT1
Tbio
Family: Enzyme
Novelty: 0.01232903
Score: 0.647
Data Source: STRINGDB
SHISA3
Tbio
Novelty: 0.12881316
Score: 0.557
Data Source: STRINGDB
KYAT3
Tbio
Family: Enzyme
Novelty: 0.05845124
Score: 0.474
Data Source: STRINGDB
HMCN2
Tdark
Novelty: 0.27717122
Score: 0.449
Data Source: STRINGDB
ITGBL1
Tbio
Novelty: 0.03669684
Score: 0.423
Data Source: STRINGDB
IRF2BP2
Tbio
Novelty: 0.06703794
Score: 0.409
Data Source: STRINGDB
VWA1
Tbio
Novelty: 0.00212445
Score: 0.408
Data Source: STRINGDB
Publication Statistics
PubMed Score  10.15

PubMed score by year
PubTator Score  3.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer