Tbio TRABD2B Metalloprotease TIKI2

Protein Classes

PANTHER Classes

Protein / ... / Metalloprotease / Metalloprotease Tiki2

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Metalloprotease Tiki2

Protein Summary

Description

Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation.

Uniprot Accession IDs

• A6NFA1
• I6U4Y0

Gene Name

• TRABD2B

Ensembl ID

• ENST00000606738
• ENSP00000476820
• ENSG00000269113

Symbol

• HKAT
• TIKI2
• TIKI2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.76
microRNA	0.71
tissue	0.66
cell type or tissue	0.63
tissue sample	0.6

IDG Partner Tools

GlyGen

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.15   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 6   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.15   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 6   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (1)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	2	1	2		65.2

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 1 of 1

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	2		65.2

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Gene Ontology Terms (11)

Functions (3)

Components (3)

Processes (5)

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1 – 3 of 3

GO Term	Evidence	Assigned by
metalloendopeptidase activity	Inferred from Direct Assay (IDA)	UniProtKB
Wnt-protein binding	Inferred from Direct Assay (IDA)	UniProtKB
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (10)

Explore Interacting Targets

1 – 10 of 10

• See Interactions on String-DB

SLC5A9

Tbio

Family: Transporter

Novelty: 0.10768341

Score: 0.762

Data Source: STRINGDB

TRABD

Tdark

Novelty: 0.47132923

Score: 0.738

Data Source: STRINGDB

AADAT

Tchem

Family: Enzyme

Novelty: 0.00678753

Score: 0.705

Data Source: STRINGDB

KYAT1

Tbio

Family: Enzyme

Novelty: 0.01232903

Score: 0.647

Data Source: STRINGDB

SHISA3

Tbio

Novelty: 0.12881316

Score: 0.557

Data Source: STRINGDB

KYAT3

Tbio

Family: Enzyme

Novelty: 0.05845124

Score: 0.474

Data Source: STRINGDB

HMCN2

Tdark

Novelty: 0.27717122

Score: 0.449

Data Source: STRINGDB

ITGBL1

Tbio

Novelty: 0.03669684

Score: 0.423

Data Source: STRINGDB

IRF2BP2

Tbio

Novelty: 0.06703794

Score: 0.409

Data Source: STRINGDB

VWA1

Tbio

Novelty: 0.00212445

Score: 0.408

Data Source: STRINGDB

Publication Statistics

PubMed Score  10.15

PubMed score by year

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PubTator Score  3.5

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

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UniProt Keyword Find Similar Targets

Cell membrane
Complete proteome
Glycoprotein
Hydrolase
Membrane
Metal-binding
Metalloprotease
Protease
Reference proteome
Signal

GWAS Trait Find Similar Targets

heel bone mineral density