Tbio TRABD2B Metalloprotease TIKI2

Protein Classes

PANTHER Classes

Protein / ... / Metalloprotease / Metalloprotease Tiki2

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Metalloprotease Tiki2

Protein Summary

Description

Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation.

Uniprot Accession IDs

• A6NFA1
• I6U4Y0

Gene Name

• TRABD2B

Ensembl ID

• ENST00000606738
• ENSP00000476820
• ENSG00000269113

Symbol

• HKAT
• TIKI2
• TIKI2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.76
microRNA	0.71
tissue	0.66
cell type or tissue	0.63
tissue sample	0.6

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.45   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 6   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.45   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 6   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
vitamin D measurement	EFO_0004631	1	1	1		48.5
heel bone mineral density	EFO_0009270	3	2	3		47.5
balding measurement	EFO_0007825	1	1	1		35

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
vitamin D measurement	EFO_0004631	1		48.5
heel bone mineral density	EFO_0009270	3		47.5
balding measurement	EFO_0007825	1		35

Reset Zoom  Beta Count   Odds Ratio

Orthologs (3)

1 – 3 of 3

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	TraB domain containing 2B	MGI:3650152	666048
Rat	TraB domain containing 2B	RGD:1586386	689914
Horse	TraB domain containing 2B	VGNC:24452	100063464

Species	Name	OMA	EggNOG	Inparanoid
Mouse	TraB domain containing 2B
Rat	TraB domain containing 2B
Horse	TraB domain containing 2B

Protein Structure (0 Structures, 1 AlphaFold Model)

tutorial

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-A6NFA1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (11)

Functions (3)

Components (3)

Processes (5)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
metalloendopeptidase activity	Inferred from Direct Assay (IDA)	UniProtKB
Wnt-protein binding	Inferred from Direct Assay (IDA)	UniProtKB
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (10)

Explore Interacting Targets

1 – 10 of 10

• See Interactions on String-DB

SLC5A9

Tbio

Family:  Transporter

Novelty:  0.10768341

Score:  0.762

Data Source:  STRINGDB

TRABD

Tdark

Novelty:  0.47132923

Score:  0.738

Data Source:  STRINGDB

AADAT

Tchem

Family:  Enzyme

Novelty:  0.00678753

Score:  0.705

Data Source:  STRINGDB

KYAT1

Tbio

Family:  Enzyme

Novelty:  0.01232903

Score:  0.647

Data Source:  STRINGDB

SHISA3

Tbio

Novelty:  0.12881316

Score:  0.557

Data Source:  STRINGDB

KYAT3

Tbio

Family:  Enzyme

Novelty:  0.05845124

Score:  0.474

Data Source:  STRINGDB

HMCN2

Tdark

Novelty:  0.27717122

Score:  0.449

Data Source:  STRINGDB

ITGBL1

Tbio

Novelty:  0.03669684

Score:  0.423

Data Source:  STRINGDB

IRF2BP2

Tbio

Novelty:  0.06703794

Score:  0.409

Data Source:  STRINGDB

VWA1

Tbio

Novelty:  0.00212445

Score:  0.408

Data Source:  STRINGDB

Publication Statistics

PubMed Score  10.45

PubMed score by year

Reset Zoom

PubTator Score  3.5

PubTator score by year

Reset Zoom

Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Cell membrane
Complete proteome
Glycoprotein
Hydrolase
Membrane
Metal-binding
Metalloprotease
Protease
Reference proteome
Signal

GWAS Trait Find Similar Targets

No Header	No Header
balding measurement
heel bone mineral density
vitamin D measurement