Tbio IZUMO1R Sperm-egg fusion protein Juno

Protein Summary

Description

Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate.

Uniprot Accession IDs

• A6ND01

Gene Name

• IZUMO1R

Ensembl ID

• ENST00000328458
• ENSP00000332963
• ENSG00000183560
• ENST00000440961
• ENSP00000416935

Symbol

• FOLR4
• JUNO
• JUNO
• FOLR4
• Folbp3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell line	0.62
molecular function	0.6
cell type or tissue	0.49
metabolite	0.45
tissue	0.43

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.72   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 243   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.72   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0