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Tbio
IZUMO1R
Sperm-egg fusion protein Juno

Protein Summary
Description
Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328458
  • ENSP00000332963
  • ENSG00000183560
  • ENST00000440961
  • ENSP00000416935

Symbol
  • FOLR4
  • JUNO
  • JUNO
  • FOLR4
  • Folbp3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.62
molecular function
0.6
cell type or tissue
0.49
metabolite
0.45
tissue
0.43


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.72   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.72   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0