Tbio CCDC88B Coiled-coil domain-containing protein 88B

Protein Summary

Description

Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4(+) and the CD8(+) compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation (By similarity). Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering to MTOC (PubMed:25762780). Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis (PubMed:21289099). This gene encodes a member of the hook-related protein family. Members of this family are characterized by an N-terminal potential microtubule binding domain, a central coiled-coiled and a C-terminal Hook-related domain. The encoded protein may be involved in linking organelles to microtubules. [provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• A6NC98
• A5D8Y5
• B5MDM2
• Q05BL2
• Q6RUV3
• Q8N1Q6
• Q8NF44
• Q9H0H1

Gene Name

• CCDC88B

Ensembl ID

• ENST00000301897
• ENSP00000301897
• ENSG00000168071
• ENST00000356786
• ENSP00000349238

Symbol

• BRLZ
• BRLZ
• HKRP3
• gipie
• CCDC88

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.74
cell type or tissue	0.64
tissue	0.55
transcription factor	0.53
virus perturbation	0.5

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Coiled-coil Domain-containing Protein 88b

Protein / Enzyme Modulator / Kinase Modulator / Coiled-coil Domain-containing Protein 88b

DTO Classes

Protein / Enzyme Modulator / Kinase Modulator / Coiled-coil Domain-containing Protein 88b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.31   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 44   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.31   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 44   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0