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Tbio
CCDC88B
Coiled-coil domain-containing protein 88B

Protein Summary
Description
Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4(+) and the CD8(+) compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation (By similarity). Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering to MTOC (PubMed:25762780). Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis (PubMed:21289099). This gene encodes a member of the hook-related protein family. Members of this family are characterized by an N-terminal potential microtubule binding domain, a central coiled-coiled and a C-terminal Hook-related domain. The ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301897
  • ENSP00000301897
  • ENSG00000168071
  • ENST00000356786
  • ENSP00000349238

Symbol
  • BRLZ
  • BRLZ
  • HKRP3
  • gipie
  • CCDC88
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.74
cell type or tissue
0.64
tissue
0.55
transcription factor
0.53
virus perturbation
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.66   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 44   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.66   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 44   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (15)
1 – 10 of 15
HOOK1
Tbio
Novelty:  0.04136856
Score:  0.71
Data Source:  STRINGDB
GNAI3
Tbio
Novelty:  0.03484857
Score:  0.635
Data Source:  STRINGDB
DOCK8
Tbio
Novelty:  0.0067047
Score:  0.596
Data Source:  STRINGDB
ZNF684
Tdark
Family:  TF
Novelty:  7.06924999
Score:  0.593
Data Source:  STRINGDB
PBX2
Tbio
Family:  TF
Novelty:  0.01339291
Score:  0.552
Data Source:  STRINGDB
COPB1
Tbio
Novelty:  0.0078407
Score:  0.529
Data Source:  STRINGDB
CCDC17
Tdark
Novelty:  1.31994153
Score:  0.523
Data Source:  STRINGDB
HSPA5
Tchem
Novelty:  0.00043424
Score:  0.521
Data Source:  STRINGDB
FAM151B
Tdark
Novelty:  2.00049418
Score:  0.517
Data Source:  STRINGDB
NUDT22
Tbio
Novelty:  0.44528464
Score:  0.489
Data Source:  STRINGDB
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
GWAS Traits (44)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
1
5
5
95.7
waist-hip ratio
2
5
5
93.9
BMI-adjusted waist-hip ratio
5
5
8
93.8
mean corpuscular volume
1
3
3
87
high density lipoprotein cholesterol measurement
4
2
4
83.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
5
95.7
waist-hip ratio
5
93.9
BMI-adjusted waist-hip ratio
8
93.8
mean corpuscular volume
3
87
high density lipoprotein cholesterol measurement
4
83.8
Find similar targets by:
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 88B
VGNC:3162
742352
Mouse
MGI:1925567
78317
Rat
RGD:1311475
293698
Dog
coiled-coil domain containing 88B
VGNC:38868
483762
Horse
coiled-coil domain containing 88B [Source:HGNC Symbol;Acc:HGNC:26757]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 88B
Mouse
Rat
Dog
coiled-coil domain containing 88B
Horse
coiled-coil domain containing 88B [Source:HGNC Symbol;Acc:HGNC:26757]
Publication Statistics
PubMed Score 10.66
PubMed score by year
PubTator Score 4.42
PubTator score by year