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Tbio
TMEM150B
Modulator of macroautophagy TMEM150B

Protein Summary
Description
Modulator of macroautophagy that causes accumulation of autophagosomes under basal conditions and enhances autophagic flux (PubMed:25929859). Represses cell death and promotes long-term clonogenic survival of cells grown in the absence of glucose in a macroautophagy-independent manner (PubMed:25929859). May have some role in extracellular matrix engulfment or growth factor receptor recycling, both of which can modulate cell survival (PubMed:25929859). This gene encodes a protein that belongs to the DRAM (damage-regulated autophagy modulator) family of membrane-spanning proteins. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326652
  • ENSP00000320757
  • ENSG00000180061

Symbol
  • TMEM224
  • TTN2
  • DRAM3
  • TMEM224
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.88
tissue sample
0.64
disease
0.62
gene perturbation
0.47
chemical
0.41


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.77   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 53   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.77   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
4
2
4
94.7
appendicular lean mass
3
1
3
81.3
mean reticulocyte volume
1
1
1
77.1
mean corpuscular hemoglobin concentration
1
1
1
61
osteoarthritis, hip
2
1
0
1.3
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
4
94.7
appendicular lean mass
3
81.3
mean reticulocyte volume
1
77.1
mean corpuscular hemoglobin concentration
1
61
osteoarthritis, hip
0
1.3
54.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 150B
VGNC:2225
456301
Macaque
transmembrane protein 150B
700419
Mouse
MGI:2679718
330460
Rat
RGD:1306181
308346
Dog
transmembrane protein 150B
VGNC:47482
611328
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 150B
Macaque
transmembrane protein 150B
Mouse
Rat
Dog
transmembrane protein 150B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-A6NC51-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (6)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (13)
1 – 10 of 13
SYCP2L
Tdark
Novelty:  0.19013847
Score:  0.756
Data Source:  STRINGDB
BRSK1
Tchem
Family:  Kinase
Novelty:  0.0267976
Score:  0.669
Data Source:  STRINGDB
MCM8
Tbio
Family:  Enzyme
Novelty:  0.02602136
Score:  0.651
Data Source:  STRINGDB
HK3
Tbio
Family:  Kinase
Novelty:  0.0151241
Score:  0.543
Data Source:  STRINGDB
UIMC1
Tbio
Novelty:  0.02039732
Score:  0.507
Data Source:  STRINGDB
METAP1D
Tbio
Family:  Enzyme
Novelty:  0.17714714
Score:  0.477
Data Source:  STRINGDB
COL4A3BP
Tbio
Novelty:  0.00357203
Score:  0.473
Data Source:  STRINGDB
PRIM1
Tbio
Family:  Enzyme
Novelty:  0.0530384
Score:  0.443
Data Source:  STRINGDB
ZNF483
Tdark
Family:  TF
Novelty:  0.39891191
Score:  0.441
Data Source:  STRINGDB
POLG
Tchem
Family:  Enzyme
Novelty:  0.00172189
Score:  0.434
Data Source:  STRINGDB
Publication Statistics
PubMed Score  7.77

PubMed score by year
PubTator Score  1.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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